TITLE

The Role of the Novel Adipocyte-Derived Protein Adiponectin in Human Disease: An Update

AUTHOR(S)
D�ez, Juan J.; Iglesias, P.
PUB. DATE
August 2010
SOURCE
Mini Reviews in Medicinal Chemistry;Aug2010, Vol. 10 Issue 9, p856
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Adiponectin is a collagen-like protein expressed in adipose tissue. Low serum adiponectin is associated with insulin resistance, atherogenic hyperlipidemia and arterial hypertension. High serum adiponectin predicted a reduced risk of myocardial infarction. Other surveys have shown that high levels of serum adiponectin were a predictor of future cardiovascular disease and mortality. These paradoxical findings might be explained through the concept of the reversal epidemiology in the adiponectin physiology. According to this hypothesis, this protein would behave as an insulin sensitizing and cardioprotective factor in the health state and as a wasting marker in the advanced states of disease.
ACCESSION #
52415892

 

Related Articles

  • Induction of Uncoupling Protein-2 (UCP2) Gene Expression on the Differentiation of Rat Preadipocytes to Adipocytes in Primary Culture. Myoung-Sool Do; Jong-Bae Kim; Taek-Joon Yoon; Choon-Ho Park; Rayner, D. Vernon; Trayhurn, Paul // Molecules & Cells (Springer Science & Business Media B.V.);1999, Vol. 9 Issue 1, p20 

    Presents information on a study which examined uncoupling protein-2 gene expression in the adipose tissue of obese and normal rats and mice. Materials and methods; Results and discussion.

  • Gene expression of tendon markers in mesenchymal stromal cells derived from different sources. Burk, Janina; Gittel, Claudia; Heller, Sandra; Pfeiffer, Bastian; Paebst, Felicitas; Ahrberg, Annette B.; Brehm, Walter // BMC Research Notes;2014, Vol. 7 Issue 1, p1 

    Background Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known...

  • Gene expression of angiotensinogen in adipose tissue of obese patients. Giacchetti, G; Faloia, E; Sardu, C; Camilloni, M A; Mariniello, B; Gatti, C; Garrapa, G G M; Guerrieri, M; Mantero, F // International Journal of Obesity & Related Metabolic Disorders;Jun2000 Supplement, Vol. 24, pS142 

    Recently, the genes of components of the renin - angiotensin system (RAS), namely angiotensinogen (AGT), angiotensin converting enzyme and angiotensin II receptor have been described in adipose tissue. In animal models the angiotensinogen in adipose tissue has been implicated in the pathogenesis...

  • In vivo modulation of Hmgic reduces obesity. Anand, Ashim; Chada, Kiran // Nature Genetics;Apr2000, Vol. 24 Issue 4, p377 

    The HMGI family of proteins consists of three members, HMGIC, HMGI and HMGI(Y), that function as architectural factors and are essential components of the enhancesome. HMGIC is predominantly expressed in proliferating, undifferentiated mesenchymal cells and is not detected in adult tissues. It...

  • The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Wang, Jiali; Liu, Rong; Liu, LiSen; Chowdhury, Rahena; Barzilai, Nir; Tan, Jianzhen; Rossetti, Luciano // Nature Medicine;Aug1999, Vol. 5 Issue 8, p895 

    Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression...

  • Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue. Ducluzeau, Pierre-Henri; Perretti, Noel; Laville, Martine; Andreelli, Fabrizio; Vega, Nathalie; Riou, Jean-Paul; Vidal, Hubert // Diabetes;May2001, Vol. 50 Issue 5, p1134 

    Reports on the characterization of the concerted regulation by insulin of the expression of ten genes related to insulin action in skeletal muscle and in subcutaneous adipose tissue. Possible involvement of defective regulation of gene expression in the pathogenesis of type 2 diabetes; Effects...

  • Deletion of Serum Amyloid A3 Improves High Fat High Sucrose Diet-Induced Adipose Tissue Inflammation and Hyperlipidemia in Female Mice. den Hartigh, Laura J.; Wang, Shari; Goodspeed, Leela; Ding, Yilei; Averill, Michelle; Subramanian, Savitha; Wietecha, Tomasz; O'Brien, Kevin D.; Chait, Alan // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Serum amyloid A (SAA) increases in response to acute inflammatory stimuli and is modestly and chronically elevated in obesity. SAA3, an inducible form of SAA, is highly expressed in adipose tissue in obese mice where it promotes monocyte chemotaxis, providing a mechanism for the macrophage...

  • SRC-3 deficient mice developed fat redistribution under high-fat diet. Lingyan Xu; Xinran Ma; Jieli Li; Xiaoying Li; Jianming Xu; Shu Wang; Guang Ning // Endocrine (1355008X);Aug2010, Vol. 38 Issue 1, p60 

    n emerging concept suggests that an aberrant distributed body fat is closely linked to the occurrence of metabolic abnormalities. Mice deficient in steroid receptor coactivator-3 (SRC-3) are shown to be protected against high-fat diet (HFD) induced obesity but little is known about whether...

  • PPAR-Ï’ Activation Mediates Adipose Depot---Specific Effects on Gene Expression and Lipoprotein Lipase Activity. Laplante, Mathieu; Sell, Henrike; MacNaul, Karen L.; Richard, Denis; Berger, Joel P.; Deshaies, Yves // Diabetes;Feb2003, Vol. 52 Issue 2, p291 

    This study sought to determine whether the adipose depot-specific (subcutaneous [SF] vs. visceral [VF]) action of peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists on fat deposition extends to the expression of lipoprotein lipase (LPL) and other key adipose lipid metabolism...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics