TITLE

Impact of Baseline Antiretroviral Resistance Status on Efficacy Outcomes Among Patients Receiving Maraviroc Plus Optimized Background Therapy in the MOTIVATE 1 and 2 Trials

AUTHOR(S)
Nelson, Mark; Fisher, Martin; Gonzalez-Garcia, Juan; Rockstroh, Jürgen K.; Weinstein, David; Valdez, Hernan; Mayer, Howard; van der Ryst, Elna; Goodrich, James M.; Dang, Nathalie
PUB. DATE
May 2010
SOURCE
HIV Clinical Trials;May/Jun2010, Vol. 11 Issue 3, p145
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: The MOTIVATE studies assessed maraviroc with optimized background therapy (OBT) in treatment-experienced patients with R5 HIV-1. This post hoc analysis compared outcomes between patients with and without HIV-1 resistance to ε3 classes of antiretrovirals at screening (triple-class-resistant [TCR] versus not-TCR [nTCR]). Methods: Week 48 changes (N = 635) in HIV-1 RNA and CD4 + cells were compared between TCR and nTCR groups receiving twice-daily maraviroc+OBT or placebo+OBT. Results: HIV-1 RNA change from baseline on maraviroc was significantly greater in the nTCR group (–2.05 vs –1.74 log10 copies/mL; 95% CI difference 0.05–0.58 log10) though proportions <400 or <50 copies/mL were not. Week 48 CD4 increases were significantly greater in the nTCR group overall (mean +150 vs +110 cells/mm3; 95% CI difference 18–62 cells/mm3) and in those with <50 RNA copies/mL (nTCR +192 vs +126 cells/mm3; 95% CI difference, 19–93 cells/mm3) or receiving ε2 active OBT agents (weighted score; nTCR +184 vs +125 cells/mm3; 95% CI difference 8–110 cells/mm3). Conclusions: Virologic suppression on maraviroc was greater in the nTCR than the TCR group, though proportions <50 or 400 copies/mL were not significantly different. Optimal CD4 increases on maraviroc appeared to accrue from initiation before development of TCR virus.
ACCESSION #
53110445

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics