TITLE

Risk factors and correlates for anemia in HIV treatment-naive infected patients: a cross-sectional analytical study

AUTHOR(S)
Mata-Marín, José A.; Gaytán-Martínez, Jesús E.; Martínez-Martínez, Rosa E.; Arroyo-Anduiza, Carla I.; Fuentes-Allen, José L.; Casarrubias-Ramirez, Moisés
PUB. DATE
January 2010
SOURCE
BMC Research Notes;2010, Vol. 3, p230
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Hematologic manifestations of the human immunodeficiency virus (HIV) infection are a well-recognized complication of the disease and may be clinically important. Our objective was to determine the risk factors for anemia and its correlation with HIV treatment-naïve infected patients without co-infection or opportunistic diseases. Findings: We performed a cross-sectional comparative study in which HIV treatment-naïve infected patients with anemia were compared with a control group of HIV patients without anemia. The interrelationship between risk factors and anemia was determined. Odds ratio and 95% confidence intervals were calculated, to adjust for the effects of potential confounders and we used a logistic regression model. Pearson's correlation coefficient was obtained to calculate the correlation between risk factors and hemoglobin. We enrolled 54 men and 9 women. Anemia was found in 13 patients; prevalence .20 (CI 95% 0.12-0.32). Severe anemia was found in only one patient (1.5%). Only CD4+ Cells Count <200 cells/mm³ was associated with increased risk of anemia in the multivariate analysis. There was a moderately strong, positive correlation between WBC and hemoglobin (r = 0.49, P < 0.001) and between CD4+ cell count and hemoglobin (r = 0.595, P < 0.001) and a moderately strong, negative correlation between HIV RNA viral load and hemoglobin (r = - 0.433, P < 0.001). Conclusions: Anemia is a common manifestation in the Mexican population without antiretroviral therapy. In HIV naïve patients a CD4+ Cell Count < 200 cells/mm³ was associated with an increased risk of anemia. There is a positive correlation between hemoglobin and CD4+ cell count.
ACCESSION #
54301032

 

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