The effect of acute exercise on glycogen synthesis rate in obese subjects studied by C MRS

van der Graaf, Marinette; de Haan, Jacco H.; Smits, Paul; Mulder, Alexandra H.; Heerschap, Arend; Tack, Cees J.
January 2011
European Journal of Applied Physiology;Jan2011, Vol. 111 Issue 2, p275
Academic Journal
In obesity, insulin-stimulated glucose uptake in skeletal muscle is decreased. We investigated whether the stimulatory effect of acute exercise on glucose uptake and subsequent glycogen synthesis was normal. The study was performed on 18 healthy volunteers, 9 obese (BMI = 32.6 ± 1.2 kg/m, mean ± SEM) and 9 lean (BMI = 22.0 ± 0.9 kg/m), matched for age and gender. All participants underwent a euglycemic hyperinsulinemic clamp, showing reduced glucose uptake in the obese group ( P = 0.01), during which they performed a short intense local exercise (single-legged toe lifting). Dynamic glucose incorporation into glycogen in the gastrocnemius muscle before and after exercise was assessed by C magnetic resonance spectroscopy combined with infusion of [1-C]glucose. Blood flow was measured to investigate its potential contribution to glucose uptake. Before exercise, glycogen synthesis rate tended to be lower in obese subjects compared with lean (78 ± 14 vs. 132 ± 24 μmol/kg muscle/min; P = 0.07). Exercise induced highly significant rises in glycogen synthesis rates in both groups, but the increase in obese subjects was reduced compared with lean (112 ± 15 vs. 186 ± 27 μmol/kg muscle/min; P = 0.03), although the relative increase was similar (184 ± 35 vs. 202 ± 51%; P = 0.78). After exercise, blood flow increased equally in both groups, without a temporal relationship with the rate of glycogen synthesis. In conclusion, this study shows a stimulatory effect of a short bout of acute exercise on insulin-induced glycogen synthesis rate that is reduced in absolute values but similar in percentages in obese subjects. These results suggest a shared pathway between insulin- and exercise-induced glucose uptake and subsequent glycogen synthesis.


Related Articles

  • Metabolic and cardiovascular responses to upright cycle exercise with leg blood flow reduction. Ozaki, Hayao; Brechue, William F.; Sakamaki, Mikako; Yasuda, Tomohiro; Nishikawa, Masato; Aoki, Norikazu; Ogita, Futoshi; Abe, Takashi // Journal of Sports Science & Medicine;Jun2010, Vol. 9 Issue 2, p224 

    The purpose of this study was to examine the metabolic and cardiovascular response to exercise without (CON) or with (BFR) restricted blood flow to the muscles. Ten young men performed upright cycle exercise at 20, 40, and 60% of maximal oxygen uptake, VO2max in both conditions while metabolic...

  • Vertical whole-body vibration does not increase cardiovascular stress to static semi-squat exercise. Hazell, Tom J.; Thomas, Graeme W. R.; DeGuire, Jason R.; Lemon, Peter W. R. // European Journal of Applied Physiology;Nov2008, Vol. 104 Issue 5, p903 

    The purpose of this study was to determine the effect of vertical whole-body vibration (WBV) on heart rate (HR), mean arterial pressure (MAP), femoral artery blood flow (FBF), and leg skin temperature (LSk(temp)) during static exercise. These parameters were examined: seated next to the WBV...

  • Different vascular responses in glabrous and nonglabrous skin with increasing core temperature during exercise. Yamazaki, Fumio; Sone, Ryoko // European Journal of Applied Physiology;Jul2006, Vol. 97 Issue 5, p582 

    To elucidate the characteristics of vasomotor control in glabrous and nonglabrous skin during dynamic exercise, we compared the vascular responses in both areas to increasing core temperature during the cycle exercise for 30 min at different intensities in the range 20–60% of peak oxygen...

  • Cardiovascular responses to static extension and flexion of arms and legs. Tokizawa, Ken; Mizuno, Masaki; Hayashi, Naoyuki; Muraoka, Isao // European Journal of Applied Physiology;May2006, Vol. 97 Issue 2, p249 

    This study compared cardiovascular responses to static extension and flexion exercises at four upper and lower limb joints. Eight males performed a 2 min static contraction at 30% of maximal voluntary torque followed immediately by 2 min post-exercise muscle ischaemia (PEMI) using each of four...

  • Heterogeneous oxygenation in nonexercising triceps surae muscle during contralateral isometric exercise. Mizuno, Masaki; Tokizawa, Ken; Muraoka, Isao // European Journal of Applied Physiology;May2006, Vol. 97 Issue 2, p181 

    To test whether changes in oxygenation of a resting skeletal muscle, evoked by a static contraction in a contralateral muscle, is uniform within a given skeletal muscle, we used near-infrared spectroscopy (NIRS). Seven subjects performed 2 min static knee extension exercise at 30% of maximal...

  • Blood flow restriction does not result in prolonged decrements in torque. Loenneke, Jeremy; Thiebaud, Robert; Fahs, Christopher; Rossow, Lindy; Abe, Takashi; Bemben, Michael // European Journal of Applied Physiology;Apr2013, Vol. 113 Issue 4, p923 

    We sought to determine if blood flow restriction (BFR) by itself or in combination with exercise would result in prolonged decrements in torque when using restriction pressures relative to the participants' limb size. Sixteen participants were randomized into Experiment A ( n = 9) or Experiment...

  • Drug Boosts Bloodflow in CHF. Bright, Jennifer; Harrar, Sari // Prevention;Aug2001, Vol. 53 Issue 8, p172 

    Reports on a study on an experimental intravenous drug, tezosentan, which improves blood flow.

  • steal.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2198 

    A definition of the term "steal," which refers to the derivation of blood flow from its normal course or rate of flow, is presented.

  • The John Sutton Lecture: CSEP, 2002 Pulmonary System Limitations to Exercise in Health. Dempsey, Jerome A.; Sheel, A. William; Haverkamp, Hans C.; Babcock, Mark A.; Harms, Craig A. // Canadian Journal of Applied Physiology;2003 Supplement, Vol. 28, pS2 

    It is commonly held that the structural capacity of the normal lung is ‘overbuilt’ and exceeds the demandfor pulmonary O2 and CO2 transport in the healthy, exercising human. On the other hand, the adaptability of pulmonary system structures to habitual physical training is...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics