Rational Use of Amikacin in Children

Arshad, Anila; Rehman, Sabahat; Zaka, Maryam; Mahmood, Khawaja Tahir
January 2011
Journal of Pharmaceutical Sciences & Research;2011, Vol. 3 Issue 1, p995
Academic Journal
Amikacin, an aminoglycoside, is used against Gram -ive and Gram +ive microorganisms for treating Sepsis, Meningitis, Jaundice neonatum, Respiratory diseases and Urinary Tract Infections. A retrospective study on Rational use of Amikacin in children was carried out to review the rationality of prescribing Amikacin, evaluating the dose, route, timing, duration of the drug, Drug interactions, therapeutic drug monitoring , Adverse Drug Reaction monitoring and reporting, awareness of nurses and other paramedical staff, role of pharmacist in the treatment and in providing pharmaceutical care to the patient and the collaboration amongst the health care professionals for carrying out the whole treatment. A total of 130 children were involved in this study from Children Hospital Lahore, Services Institute of Medical Sciences Lahore and renowned general physicians. 94.61% patients had been receiving Amikacin therapy empirically, 80.76% patients had completed their therapy within 10 days, and 86.15% of patients had their culture sensitivity reports attached to their profiles. Resistance was seen in 11.53% patients. 90.77% patients had been irrationally prescribed with Cephalosporins and amongst 24.95% patients, the drug interactions were observed. 59.23% cases were only supervised by the pharmacist. Amikacin had been rationally prescribed as an empiric therapy with duration of less than 10 days but it had been irrationally prescribed when given alongwith interacting drugs. It had been rationally stored and administered by the nursing staff with a little supervision of pharmacist and a little provision of pharmaceutical care. Proper therapeutic drug monitoring and consequent dosage adjustment were provided rarely.


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