TITLE

Pharmacogenetics and Clopidogrel Response in Patients Undergoing Percutaneous Coronary Interventions

AUTHOR(S)
Beitelshees, A. L.; Horenstein, R. B.; Vesely, M. R.; Mehra, M. R.; Shuldiner, A. R.
PUB. DATE
March 2011
SOURCE
Clinical Pharmacology & Therapeutics;Mar2011, Vol. 89 Issue 3, p455
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the association between cytochrome P450 2C19 (CYP2C19) and clopidogrel response in patients under percutaneous coronary interventions. It says that studies from 2008 show that CYP2C19*2 genotype increase the risk of patients to have cardiovascular events but the Platelet Inhibition and Patient Outcomes (PLATO) data reveal no relationship between outcomes and the ABCB1 genotype. It adds that physicians could continue using clopidogrel or use other antiplatelet agents.
ACCESSION #
58146000

 

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