Influence of Human Immunodeficiency Virus Type 1 Infection on Acute Hepatitis A Virus Infection

Ida, Setsuko; Tachikawa, Natsuo; Nakajima, Aya; Daikoku, Manabu; Yano, Michitami; Kikuchi, Yoshimi; Yasuoka, Akira; Kimura, Satoshi; Oka, Shinichi
February 2002
Clinical Infectious Diseases;2/1/2002, Vol. 34 Issue 3, p379
Academic Journal
To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1--infected homosexual men and 15 non--HIV-infected age-matched subjects were compared. HAV load was higher in HIV-1--infected than in non--HIV-infected patients (p<.001). Duration of viremia in HIV-1--infected patients (median, 53 days) was significantly (p<.05 ) longer than in non--HIV-infected patients (median, 22 days). HIV-1--infected patients had lower elevations in alanine aminotransferase levels than did non--HIV-infected patients (p<.01) but had higher elevations in alkaline phosphatase levels than did non--HIV-infected patients (p<.001 ). Some HIV-1--infected patients still had HAV viremia when clinical symptoms had disappeared and alanine aminotransferase levels had returned to normal (60--90 days after the onset of symptoms). HIV-1 infection was associated with prolongation of HAV viremia, which might cause a long-lasting outbreak of HAV infection in HIV-1--infected homosexual men.


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