TITLE

Impact of C-reactive protein on absolute reticulocyte count in haemodialysis patients: the role of iron status

AUTHOR(S)
Mitsopoulos, Efstathios; Tsiatsiou, Maria; Zanos, Stavros; Katodritou, Eirini; Visvardis, Georgios; Papadopoulou, Dorothea; Passadakis, Ploumis; Vargemezis, Vassilis; Tsakiris, Dimitrios
PUB. DATE
March 2011
SOURCE
Nephrology Dialysis Transplantation;Mar2011, Vol. 26 Issue 3, p992
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Τhe exact mechanisms by which the effects of inflammation on erythropoiesis occur are still to be determined. We aimed to examine the relation between C-reactive protein (CRP) and erythropoiesis as quantified by the absolute reticulocyte count (RTC) and the possible effect of iron status on this relationship.Methods. As part of a study that follows the changes of haematologic parameters after the intravenous (IV) administration of iron in 93 stable haemodialysis (HD) patients, we made a cross-sectional analysis of baseline measurements and an analysis of changes in RTC 1 week after baseline measurements and iron administration.Results. Multiple linear regression analysis revealed that RTC had a positive correlation with CRP; RTC had a negative correlation with reticulocyte haemoglobin content (CHr). An interaction was also found between CRP and CHr in that CRP had a significant relation to RTC only in those patients whose CHr was more than 31.2 pg. At lower values of CHr, the correlation between CRP and RTC was not significant. Five days after the IV administration of 200 mg iron sucrose, a significant increase of RTC was observed, only in those patients with elevated baseline CRP levels who also showed an increase in CHr levels from ≤ 31.2 pg at baseline to ≥ 31.2 pg post-administration, supporting the presence of an independent positive correlation between CRP and RTC when iron is adequate.Conclusions. It is indicated that, in HD patients, elevated CRP values are associated with increased erythroid production only when CHr is quite satisfactory.
ACCESSION #
58769164

 

Related Articles

  • Complete correction of anemia by erythropoiesis-stimulating agents is associated with insulin resistance in hemodialysis patients. Biolo, Gianni; Guarnieri, Gianfranco; Barazzoni, Rocco; Panzetta, Giovanni // Clinical & Experimental Medicine;Sep2011, Vol. 11 Issue 3, p181 

    Insulin resistance and anemia secondary to erythropoietin deficiency characterize patients with end-stage kidney disease. In a cross-sectional analysis, we examined the relationship between erythropoietin-mediated correction of anemia and insulin sensitivity in nondiabetic hemodialysis patients....

  • Geographic Variation in HMG-CoA Reductase Inhibitor Use in Dialysis Patients. Wetmore, James; Mahnken, Jonathan; Mukhopadhyay, Purna; Hou, Qingjiang; Ellerbeck, Edward; Rigler, Sally; Spertus, John; Shireman, Theresa // JGIM: Journal of General Internal Medicine;Nov2012, Vol. 27 Issue 11, p1475 

    Background: Despite uncertainty about their effectiveness in chronic dialysis patients, statin use has increased in recent years. Little is known about the demographic, clinical, and geographic factors associated with statin exposure in end-stage renal disease (ESRD) patients. Objective: To...

  • Is N-terminal probrain-type natriuretic peptide a clinically useful biomarker of volume overload in peritoneal dialysis patients? Papakrivopoulou, Eugenia; Lillywhite, Samuel; Davenport, Andrew // Nephrology Dialysis Transplantation;Jan2012, Vol. 27 Issue 1, p396 

    Background. Brain natriuretic peptide (BNP) has been reported to be a powerful predictor of peritoneal dialysis patient survival. However, it is unclear as to whether this is related to cardiac dysfunction or chronic volume overload. Methods. To investigate the relationship between BNP, cardiac...

  • Broadening Options for Long-term Dialysis in the Elderly (BOLDE): differences in quality of life on peritoneal dialysis compared to haemodialysis for older patients. Brown, Edwina A.; Johansson, Lina; Farrington, Ken; Gallagher, Hugh; Sensky, Tom; Gordon, Fabiana; Da Silva-Gane, Maria; Beckett, Nigel; Hickson, Mary // Nephrology Dialysis Transplantation;Nov2010, Vol. 25 Issue 11, p3755 

    Background. Health-related quality of life (QOL) is an important outcome for older people who are often on dialysis for life. Little is, however, known about differences in QOL on haemodialysis (HD) and peritoneal dialysis (PD) in older age groups. Randomising patients to either modality to...

  • Anemia of Inflammation Is Related to Cognitive Impairment among Children in Leyte, The Philippines. Olson, Courtney L.; Acosta, Luz P.; Hochberg, Natasha S.; Olveda, Remigio M.; Jiz, Mario; McGarvey, Stephen T.; Kurtis, Jonathan D.; Bellinger, David C.; Friedman, Jennifer F. // PLoS Neglected Tropical Diseases;Oct2009, Vol. 3 Issue 10, p1 

    Background: Many studies have addressed the relationship between iron deficiency anemia (IDA) and cognitive impairment, but none have evaluated the role of non-iron deficiency anemia (NIDA). One of the main causes of NIDA in developing countries is AI, largely due to infectious diseases, whereby...

  • Reticulocyte dynamic and hemoglobin variability in hemodialysis patients treated with Darbepoetin alfa and C.E.R.A.: a randomized controlled trial. Forni, Valentina; Bianchi, Giorgia; Ogna, Adam; Salvadé, Igor; Vuistiner, Philippe; Burnier, Michel; Gabutti, Luca // BMC Nephrology;2013, Vol. 14 Issue 1, p1 

    Background: In a simulation based on a pharmacokinetic model we demonstrated that increasing the erythropoiesis stimulating agents (ESAs) half-life or shortening their administration interval decreases hemoglobin variability. The benefit of reducing the administration interval was however...

  • Health-related quality of life among hemodialysis patients at El-Minia University Hospital, Egypt. Kamal, Nashwa; Kamel, Emad; Eldessouki, Khaled; Ahmed, Marwa // Journal of Public Health (09431853);Apr2013, Vol. 21 Issue 2, p193 

    Background: Hemodialysis results in significant change in daily living, physical and psychological impairments, disruption of marital, family, and social life. Health-related quality of life (HRQOL) assessment helps to plan individual treatment strategies, and determine the efficacy, quality of...

  • Factors Associated with D-Dimer Levels in HIV-Infected Individuals. Borges, Álvaro H.; O’Connor, Jemma L.; Phillips, Andrew N.; Baker, Jason V.; Vjecha, Michael J.; Losso, Marcelo H.; Klinker, Hartwig; Lopardo, Gustavo; Williams, Ian; Lundgren, Jens D. // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Background: Higher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV infection, however, remain poorly understood. Methods: In this cross-sectional study, participants in three randomized controlled trials with...

  • Relationship between periodontal inflammation and fetal growth in pregnant women: a cross-sectional study. Takeuchi, Noriko; Ekuni, Daisuke; Irie, Koichiro; Furuta, Michiko; Tomofuji, Takaaki; Morita, Manabu; Watanabe, Tatsuo // Archives of Gynecology & Obstetrics;May2013, Vol. 287 Issue 5, p951 

    Purpose: Periodontal disease in pregnant women, evaluated by probing pocket depth (PPD) or clinical attachment level (CAL), significantly increases the risk of subsequent preterm birth (PB) and/or low birth weight (LBW). However, PPD and CAL do not always reflect current periodontal tissue...

Share

Read the Article

Courtesy of MICHIGAN ELIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics