TITLE

Neurogenic induction of human mesenchymal stem cells in fibrin 3D matrix

AUTHOR(S)
Shakhbazau, A. V.; Petyovka, N. V.; Kosmacheva, S. M.; Potapnev, M. P.
PUB. DATE
February 2011
SOURCE
Bulletin of Experimental Biology & Medicine;Feb2011, Vol. 150 Issue 4, p547
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We studied the potential of neurogenic induction of human bone marrow mesenchymal stem cells in fibrin-based 3D matrix. The best results were obtained after incubation of mesenchymal stem cells in fibrin 3D matrix in the presence of neurogenic medium containing EGF and bFGF growth factors. Under these conditions, most cells formed numerous branching processes and expressed neural cell marker βIII-tubulin. Optimal combination of 3D matrix and neurogenic factors of the medium can provide new insight into neurogenic potential of mesenchymal stem cells, which can be used for the therapy of neural traumas and neurodegenerative diseases.
ACCESSION #
59354923

 

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