Analysis of Resistance Testing in South Trinidad

Duke, N.; Aboh, S.; Bosivert, N.
July 2010
West Indian Medical Journal;2010 Special Issue, Vol. 59 Issue 4, p400
Academic Journal
The introduction of antiretroviral therapy in Trinidad and Tobago in the 1980s has resulted in a decrease in mortality of HIV-infected persons. Poor adherence to antiretroviral therapy (ART) has resulted in the development of multidrug resistant HIV. Resistance testing done on 40 samples showed that 64.8% of patients had K103 mutation, 75.6% of patients had M184 mutations and 62% of patients showed resistance to tenofovir suggesting that the K65R mutation was highly likely to be present. There was reduced activity to the protease inhibitors; no resistance was found to the protease inhibitor, darunavir. Thus, there is a need for salvage therapy to be introduced which will result in virologic suppression and potentially stop the spread of multidrug resistant HIV. Darunavir, a new generation protease inhibitor, is an essential part of salvage therapy and needs to be introduced into the national formulary.


Related Articles

  • The Evolution of Coreceptor Tropism in HIV-infected Patients Interrupting Suppressive Antiretroviral Therapy. Waters, Laura J.; Scourfield, Andrew T.; Marcano, Marie; Gazzard, Brian G.; Bower, Mark; Nelson, Mark; Stebbing, Justin // Clinical Infectious Diseases;3/1/2011, Vol. 52 Issue 5, p671 

    CCR5 antagonists may provide a well-tolerated switch option for patients experiencing tolerability or toxicity of their antiretroviral regimen. We analyzed stored samples from patients undergoing planned treatment interruptions for reasons other than virological failure, in order to analyze...

  • Efficacy, safety and pharmacokinetics of 900/100 mg of darunavir/ritonavir once daily in treatment-experienced patients. Curran, Adrian; Gutirerrez, Mar; Deig, Elisabet; Mateo, Gracia; Lopez, Rosa Maria; Imaz, Arkaitz; Crespo, Manuel; Ocaña, Inma; Domingo, Pere; Ribera, Esteban // Journal of Antimicrobial Chemotherapy (JAC);Oct2010, Vol. 65 Issue 10, p2195 

    Objectives: To evaluate the virological efficacy, safety, tolerability and pharmacokinetics of a regimen containing 900/100 mg of ritonavir-boosted darunavir once daily in patients with antiretroviral experience but no darunavir resistance.

  • Trends in Antiretroviral Drug Use During Pregnancy Among HIV-Infected Women on Medicaid: 2000-2007. Phiri, Kelesitse; Fischer, Michael A.; Mogun, Helen; Williams, Paige L.; Palmsten, Kristin; Seage, George R.; Hernandez-Diaz, Sonia // AIDS Patient Care & STDs;Feb2014, Vol. 28 Issue 2, p56 

    Optimal use of antiretroviral drugs by pregnant women living with human immunodeficiency virus (HIV) is crucial to treat maternal HIV infection and prevent perinatal transmission of the virus effectively. Our goal was to describe national trends of antiretroviral (ARV) use during pregnancy among...

  • High Risk Features Contrast With Favorable Outcomes in HIV-associated Hodgkin Lymphoma in the Modern cART Era, ANRS CO16 LYMPHOVIR Cohort. Besson, Caroline; Lancar, Remi; Prevot, Sophie; Brice, Pauline; Meyohas, Marie-Caroline; Marchou, Bruno; Gabarre, Jean; Bonnet, Fabrice; Goujard, Cécile; Lambotte, Olivier; Boué, François; Mounier, Nicolas; Partisani, Marialuisa; Raffi, Francois; Costello, Régis; Hendel-Chavez, Houria; Algarte-Genin, Michele; Trabelsi, Selma; Marchand, Lucie; Raphael, Martine // Clinical Infectious Diseases;11/1/2015, Vol. 61 Issue 9, p1469 

    Background: Human immunodeficiency virus (HIV) infection is associated with a high risk of classical Hodgkin's lymphoma (cHL) in the combined antiretroviral therapy (cART) era. Methods: We analyzed the characteristics and outcome of HIV-associated cHL diagnosed in the modern cART era. The French...

  • Clinical Performance of a Dermal Filler Containing Natural Glycolic Acid and a Polylactic Acid Polymer. Tagle, Jorge M.; Macchetto, Pedro Cervantes; Páramo, Rosa Margarita Durán // Journal of Clinical & Aesthetic Dermatology;Feb2010, Vol. 3 Issue 2, p42 

    Lipoatrophy is a condition that affects certain individuals, most commonly those who are infected with the human immunodeficiency virus. Injectable fillers are used for the treatment of these dermal contour deformities to smooth dermal depressions formed by the loss of volume. These dermal...

  • Transmission of HIV-1 Drug-Resistant Variants: Prevalence and Effect on Treatment Outcome. Jakobsen, Martin R.; Tolstrup, Martin; Søgaard, Ole S.; Jørgensen, Louise B.; Gorry, Paul R.; Laursen, Alex; Østergaard, Lars // Clinical Infectious Diseases;2/15/2010, Vol. 50 Issue 4, p566 

    Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance is an important threat to the overall success of antiretroviral therapy (ART). Because of the limited sensitivity of commercial assays, transmitted drug resistance (TDR) may be underestimated; thus, the effect that TDR has...

  • Safety Aspects of Antiretroviral Therapy for Management of HIV Infection. Rajesh, R.; Vidyasagar, Sudha; Naren, Patel; Varghese, Manju // Journal of Basic & Clinical Pharmacy;Dec/Feb2010, Vol. 1 Issue 1, p47 

    There are four classes of antiretroviral agents used in the treatment of HIV/ AIDS. Adverse effects to Highly Active Antiretroviral Therapy (HAART ) are common and often difficult to avoid. In many cases, research is not able to identify the exact cause of an adverse event. The severity of...

  • High efficacy of first-line ART in a West African cohort, assessed by dried blood spot virological and pharmacological measurements. de Truchis, Pierre; Minh Patrick Lê; Daou, Mamane; Madougou, Boubacar; Nouhou, Yacouba; Saley, Sahada Moussa; Sani, Achirou; Adehossi, Eric; Rouveix, Elisabeth; Saidou, Mamadou; Peytavin, Gilles; Delaugerre, Constance; Lê, Minh Patrick; Moussa Saley, Sahada // Journal of Antimicrobial Chemotherapy (JAC);Nov2016, Vol. 71 Issue 11, p3222 

    Objectives: The objectives of this study were to determine the rate of viral success in HIV-infected patients on first-line ART by the assessment of dried blood spot (DBS) viral load (VL) and to assess the performance of DBS sampling for VL measurement, genotypic resistance and...

  • Effectiveness of early antiretroviral therapy initiation to improve survival among HIV-infected adults with tuberculosis: a retrospective cohort study. Franke, Molly F.; Robins, James M.; Mugabo, Jules; Kaigamba, Felix; Cain, Lauren E.; Fleming, Julia G.; Murray, Megan B. // PLoS Medicine;May2011, Vol. 8 Issue 5, p1 

    Background: Randomized clinical trials examining the optimal time to initiate combination antiretroviral therapy (cART) in HIV-infected adults with sputum smear-positive tuberculosis (TB) disease have demonstrated improved survival among those who initiate cART earlier during TB...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics