TITLE

Analysis of Resistance Testing in South Trinidad

AUTHOR(S)
Duke, N.; Aboh, S.; Bosivert, N.
PUB. DATE
July 2010
SOURCE
West Indian Medical Journal;2010 Special Issue, Vol. 59 Issue 4, p400
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The introduction of antiretroviral therapy in Trinidad and Tobago in the 1980s has resulted in a decrease in mortality of HIV-infected persons. Poor adherence to antiretroviral therapy (ART) has resulted in the development of multidrug resistant HIV. Resistance testing done on 40 samples showed that 64.8% of patients had K103 mutation, 75.6% of patients had M184 mutations and 62% of patients showed resistance to tenofovir suggesting that the K65R mutation was highly likely to be present. There was reduced activity to the protease inhibitors; no resistance was found to the protease inhibitor, darunavir. Thus, there is a need for salvage therapy to be introduced which will result in virologic suppression and potentially stop the spread of multidrug resistant HIV. Darunavir, a new generation protease inhibitor, is an essential part of salvage therapy and needs to be introduced into the national formulary.
ACCESSION #
59691353

 

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