The Bioethics of iPS Cell-Based Drug Discovery

Hyun, I.
May 2011
Clinical Pharmacology & Therapeutics;May2011, Vol. 89 Issue 5, p646
Academic Journal
The ability to generate human induced pluripotent stem (iPS) cells presents exciting prospects for drug discovery and the development of safer, more effective drugs. Given the enormous potential for iPS cellbased drug development, what ethical issues could possibly cloud this new biomedical horizon?


Related Articles

  • Opportunities for Use of Human iPS Cells in Predictive Toxicology. Anson, B. D.; Kolaja, K. L.; Kamp, T. J. // Clinical Pharmacology & Therapeutics;May2011, Vol. 89 Issue 5, p754 

    The article discuses the use of human induced pluripotent stem (iPS) cells in predictive toxicology. It states that the toxicity assessment is a major challenge in cost-effective drug development and there is a need of tools to predict adverse drug reactions accurately. It describes the...

  • A New Dimension of Clinical Pharmacology: Induced Pluripotent Stem Cells. Ito, S. // Clinical Pharmacology & Therapeutics;May2011, Vol. 89 Issue 5, p629 

    The article introduces this issue of the journal Pluripotent Stem Cells (iPSCs) including one article on on human iPSC-centered approach, another on updated summary of the field and future directions of the iPSCs and one on methodology of somatic cell reprogramming and the challenges linked with...

  • Embryo-like features of induced pluripotent stem cells defy legal and ethical boundaries. Meskus, Mianna; de Miguel Beriain, IƱigo // Croatian Medical Journal;dec2013, Vol. 54 Issue 6, p589 

    The article discusses emerging ethical aspects in stem cell science following the successes made in reprogramming adult cells to become induced pluripotent stem (IPS) cells in vitro as well as in vivo conditions. Topics discussed include advantages of reprogramming cells in disease modeling and...

  • Advances and applications of induced pluripotent stem cells. Pietronave, Stefano; Prat, Maria // Canadian Journal of Physiology & Pharmacology;Mar2012, Vol. 90 Issue 3, p317 

    Direct reprogramming of somatic cells into pluripotent cells is an emerging technology for creating patient-specific cells, and potentially opens new scenarios in medical and pharmacological fields. From the discovery of Shinya Yamanaka, who first obtained pluripotent cells from fibroblasts by...

  • Analysis of Embryoid Bodies Derived from Human Induced Pluripotent Stem Cells as a Means to Assess Pluripotency. Sheridan, Steven D.; Surampudi, Vasudha; Rao, Raj R. // Stem Cells International;2012, p1 

    Human induced pluripotent stem cells (hiPSCs) have core properties of unlimited self-renewal and differentiation potential and have emerged as exciting cell sources for applications in regenerative medicine, drug discovery, understanding of development, and disease etiology. Key among numerous...

  • Stem cell systems informatics for advanced clinical biodiagnostics: tracing molecular signatures from bench to bedside. Faustino, Randolph S.; Arrell, D. Kent; Folmes, Clifford D. L.; Terzic, Andre; Perez-Terzic, Carmen // Croatian Medical Journal;Aug2013, Vol. 54 Issue 4, p319 

    The article discusses bioinformatics approaches to stem cells which possess a unique potential to anticipate disease phenotype from its derived transcriptomic, proteomic, and metabolomic strata. It also mentions about different types of stem cells including pluripotent stem cells, and embryonic...

  • Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling. Yap, May Shin; Nathan, Kavitha R.; Yeo, Yin; Lim, Lee Wei; Poh, Chit Laa; Richards, Mark; Lim, Wei Ling; Othman, Iekhsan; Heng, Boon Chin // Stem Cells International;5/25/2015, Vol. 2015, p1 

    Human pluripotent stem cells (hPSCs) derived from either blastocyst stage embryos (hESCs) or reprogrammed somatic cells (iPSCs) can provide an abundant source of human neuronal lineages that were previously sourced from human cadavers, abortuses, and discarded surgical waste. In addition to the...

  • iPSCs in Drug Discovery. Peluso, Carolyn // Drug Discovery & Development;Jul/Aug2012, Vol. 15 Issue 7, p10 

    The article discusses the significant role played by induced pluripotent stem cells (iPSCs) derived from adult somatic cells in drug discovery.

  • Medicine: Stem cells guide Alzheimer's drugs.  // Nature;2/28/2013, Vol. 494 Issue 7438, p404 

    The article discusses two studies in Japan on induced pluripotent stem (iPS) cells generated from patients with inherited and non-inherited forms of Alzheimer's disease, which suggest that patient-specific iPS cells could lead drug development to treat the disease.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics