TITLE

Pediatric Visceral Leishmaniasis in Albania: A Retrospective Analysis of 1,210 Consecutive Hospitalized Patients (1995-2009)

AUTHOR(S)
Petrela, Raida; Kuneshka, Loreta; Foto, Eli; Zavalani, Ferit; Gradoni, Luigi
PUB. DATE
September 2010
SOURCE
PLoS Neglected Tropical Diseases;Sep2010, Vol. 4 Issue 9, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Little information is available about infantile visceral leishmaniasis (VL) in Albania as regards incidence, diagnosis and management of the disease. Methodology/Principal Findings: Demographic data, clinical and laboratory features and therapeutic findings were considered in children admitted to University Hospital of Tirana from 1995 to 2009, and diagnosed as having VL. The diagnosis was based on bone-marrow microscopy/culture in 77.5% of patients, serology in 16.1%, and ex juvantibus in 6.4%. A total of 1,210 children were considered, of whom 74% came from urbanized areas. All patients were in the age range 0-14 years, with a median of 4 years. Hepatosplenomegaly was recorded in 100%, fever in 95.4% and moderate to severe anemia in 88% of cases. Concomitant conditions were frequent: 84% had bronchopneumonia; diarrhea was present in 27%, with acute manifestations in 5%; 3% had salmonellosis. First-line therapy was meglumine antimoniate for all patients, given at the standard Sbv dosage of 20 mg/kg/day for 21 to 28 days. Two children died under treatment, one of sepsis, the other of acute renal impairment. There were no cases of primary unresponsiveness to treatment, and only 8 (0.67%) relapsed within 6-12 months after therapy. These patients have been re-treated with liposomal amphotericin B, with successful cure. Conclusions: Visceral leishmaniasis in pediatric age is relatively frequent in Albania; therefore an improvement is warranted of a disease-specific surveillance system in this country, especially as regards diagnosis. Despite recent reports on decreased responses to antimonial drugs of patients with Mediterranean VL, meglumine antimoniate treatment appears to be still highly effective in Albania.
ACCESSION #
60641138

 

Related Articles

  • Evaluation of enzyme-linked immunosorbent assay in the diagnosis of kala-azar in Malda district... Gupta, Suman; Smith, Jeanette M. // JAMA: Journal of the American Medical Association;6/22/94-6/29/94, Vol. 271 Issue 24, p1890c 

    Evaluates the usefulness of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of kala-azar. Detection of antileishmanial antibodies; Antigen requirement per test; Cross-reactivity of sera from patients with other parasitic diseases; Results of follow-up monitoring.

  • Detection of Giardia lamblia antigen in stool specimens using enzyme-linked immunosorbent assay. Al-Saeed, A. T.; Issa, S. H. // Eastern Mediterranean Health Journal;abr2010, Vol. 16 Issue 4, p362 

    The aim of this study in Iraq was to determine the sensitivity and specificity of a commercial ELISA test for detection of Giardia lamblia antigen in stool. Of 84 stool samples from children in Duhok governorate, 42 were positive and 42 negative for G. lamblia or other parasites by direct and...

  • Comparison of an in-house latex agglutination test with IgM ELISA and MAT in the diagnosis of leptospirosis. Shekatkar, S.; Acharya, N. S.; Harish, B. N.; Parija, S. C. // Indian Journal of Medical Microbiology;Jul2010, Vol. 28 Issue 3, p238 

    The laboratory diagnosis of leptospirosis is fraught with several problems. Isolation of Leptospira by culture has a low sensitivity and the microscopic agglutination test (MAT) is time consuming To overcome these problems, a rapid latex agglutination test (LAT) has been standardized for the...

  • Herramientas no invasivas en Venezuela: comparación entre las pruebas inmunoserológicas DAT, rK26 y rK39 en el diagnóstico de leishmaniasis visceral. Terán-Ángel, Guillermo; Rodríguez, Vestalia; Silva, Rosilved; Zerpa, Olga; Schallig, Henk; Ulrich, Marian; Cabrera, Maira // Biomédica: Revista del Instituto Nacional de Salud;mar2010, Vol. 30 Issue 1, p39 

    Introduction. Human visceral leishmaniasis is a serious public health problem in endemic countries because of its high potential lethality, particularly in children. Rapid diagnosis is essential to early treatment and control of visceral leishmaniasis. Objective. The aim was to compare three...

  • Public Knowledge about and Detection of Canine Visceral Leishmaniasis in Urban Divinópolis, Brazil. Margonari, Carina; Menezes, Júlia Alves; Rocha, Marcele Neves; Maia, Kamila Nunes; Oliveira, Michael Éder de; Fonseca, Amanda Luisa; de Sousa, Fabrizio Furtado; Castro Ferreira, Eduardo de; Madureira, Ana Paula; Melo, Maria Norma; Soares, Rodrigo Pedro // Journal of Tropical Medicine (16879686);2012, p1 

    Background. Leishmaniases are diseases with a wide spectrumof clinical manifestations including cutaneous (CL) and visceral (VL) forms.Many factors may affect their occurrence and expansion including environmental, geographic, and social conditions. In the past two decades, Divinópolis,Minas...

  • Validity and Reliability of Enzyme Immunoassays Using Leishmania major or L. infantum Antigens for the Diagnosis of Canine Visceral Leishmaniasis in Brazil. de Arruda, Mauro Maciel; Figueiredo, Fabiano Borges; Cardoso, Fernanda Alvarenga; Hiamamoto, Roberto Mitsuyoshi; Brazuna, Júlia Cristina Macksoud; de Oliveira, Maria Regina Fernandes; Noronha, Elza Ferreira; Romero, Gustavo Adolfo Sierra // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Background: American visceral leishmaniasis is caused by the protozoan Leishmania infantum. Dogs are the main reservoirs in the domestic transmission cycle. The limited accuracy of diagnostic tests for canine leishmaniasis may contribute to the lack of impact of control measures recommended by...

  • Comparative Study of Dot Enzyme Immunoassay (Typhidot-M) and Widal Test in the Diagnosis of Typhoid Fever. NARAYANAPPA, D.; SRIPATHI, RACHANA; JAGDISHKUMAR, K.; RAJANI, H. S. // Indian Pediatrics;Apr2010, Vol. 47 Issue 4, p331 

    We compared the sensitivity and specificity of Typhidot-M and Widal test with blood culture (gold standard) for diagnosing typhoid fever in 105 children aged 1-15 years admitted with clinical suspicion of typhoid fever. Of the 105 cases, blood culture was positive for S.typhi in 41 (39%)...

  • Multi-Country Evaluation of the Sensitivity and Specificity of Two Commercially-Available NS1 ELISA Assays for Dengue Diagnosis. Guzman, Maria G.; Jaenisch, Thomas; Gaczkowski, Roger; Hang, Vo Thi Ty; Sekaran, Shamala Devi; Kroeger, Axel; Vazquez, Susana; Ruiz, Didye; Martinez, Eric; Mercado, Juan C.; Balmaseda, Angel; Harris, Eva; Dimano, Efren; Leano, Prisca Susan A.; Yoksan, Sutee; Villegas, Elci; Benduzu, Herminia; Villalobos, Iris; Farrar, Jeremy; Simmons, Cameron P. // PLoS Neglected Tropical Diseases;Aug2010, Vol. 4 Issue 8, p1 

    Background: Early diagnosis of dengue can assist patient triage and management and prevent unnecessary treatments and interventions. Commercially available assays that detect the dengue virus protein NS1 in the plasma/serum of patients offers the possibility of early and rapid diagnosis....

  • Development and evaluation of a dipstick assay in diagnosis of human fasciolosis. Ali, Nehad // Parasitology Research;May2012, Vol. 110 Issue 5, p1649 

    For the diagnosis of human fasciolosis, a new dipstick assay was developed and its diagnostic efficacy was evaluated in comparison to enzyme linked immunosorbent assay (ELISA) using Fasciola gigantica excretory-secretory antigen. Sera samples were collected from patients with confirmed...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics