TITLE

Solid dispersion: A promising technique to enhance solubility of poorly water soluble drug

AUTHOR(S)
Sharma1, Anshu; Jain, C.P.
PUB. DATE
October 2011
SOURCE
International Journal of Drug Delivery;2011, Vol. 3 Issue 4, p149
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The present review deals in detail about solid dispersion technology and its manufacturing techniques at laboratory and industrial level. This highlight about various hydrophilic polymers used in this technique to enhance solubility of poorly soluble drugs. It also discusses about modern characterization technique to characterize solid dispersion. In this review, it is intended to discuss the recent advances related on the area of solid dispersion technology
ACCESSION #
63889647

 

Related Articles

  • FORMULATION DEVELOPMENT AND IN VIVO EVALUATION OF EFAVIRENZ SOLID DISPERSIONS. Kiran Kumar, V.; Aruna devi, M.; Bhikshapathi, D. V. R. N. // International Journal of Pharmaceutical Sciences Review & Resear;Nov/Dec2012, Vol. 17 Issue 1, p97 

    The applicability of the solid dispersion technique as a method for enhancing the GI absorption of a drug has been explored in order to achieve better dissolution characteristics and better bioavailability for poorly soluble drugs. Efavirenz is an antiretroviral agent often demonstrates poor...

  • Comparative evaluation of various solubility enhancement strategies for furosemide. Murtaza, Ghulam; Khan, Shujaat Ali; Najam-ul-Haq, Muhammad; Hussain, Izhar // Pakistan Journal of Pharmaceutical Sciences;Jul2014, Vol. 27 Issue 4, p963 

    Drugs with good solubility exhibit good oral absorption, and subsequently good bioavailability. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancement of drug solubility. This review describes various traditional and novel methodologies...

  • Recent Advances in Lipid-Based Formulation Technology. Porter, Christopher J. H.; Williams, Hywel D.; Trevaskis, Natalie L. // Pharmaceutical Research;Dec2013, Vol. 30 Issue 12, p2971 

    No abstract available.

  • Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. Shweta Gupta; Rajesh Kesarla; Abdelwahab Omri // ISRN Pharmaceutics;2013, p1 

    Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60-70% of the drug molecules are insufficiently soluble in aqueous media and/or have very low permeability to allow for their adequate and reproducible absorption from the gastrointestinal...

  • SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS. Gohil, Tushar // Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia;2014, Vol. 25 Issue 1, p1 

    Aqueous solubility is a limiting factor in the oral bioavailability of a certain class of poorly water soluble drugs. A consequence of low aqueous solubility is a slow dissolution rate. For the drugs with low aqueous solubility and high permeability the dissolution rate will be the rate limiting...

  • Enhancement of Transdermal Penetration and Bioavailability of Poorly Soluble Acyclovir Using Solid Lipid Nanoparticles Incorporated in Gel Cream. GIDE, P. S.; GIDWANI, S. K.; KOTHULE, K. U. // Indian Journal of Pharmaceutical Sciences;Mar/Apr2013, Vol. 75 Issue 2, p138 

    The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in...

  • A review on bio-availability enhancement techniques of poorly soluble drug. Khan, Anwar; Malviya, Rishabha; Sharma, Pramod K. // International Journal of Pharmacy;Jul2014, Vol. 4 Issue 3, p260 

    Solubility is the process of dissolution of solid in liquid phase to give a homogenous system and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Dissolution rate of poorly water-soluble drugs is rate limiting step...

  • Solubility Enhancement of a Poorly Water Soluble Drug by Forming Solid Dispersions using Mechanochemical Activation. ROJAS-OVIEDO, I.; RETCHKIMAN-CORONA, B.; QUIRINO-BARREDA, C. T.; CÁRDENAS, J.; SCHABES-RETCHKIMAN, P. S. // Indian Journal of Pharmaceutical Sciences;Nov/Dec2013, Vol. 74 Issue 6, p505 

    Mechanochemical activation is a practical cogrinding operation used to obtain a solid dispersion of a poorly water soluble drug through changes in the solid state molecular aggregation of drug-carrier mixtures and the formation of noncovalent interactions (hydrogen bonds) between two crystalline...

  • SOLID DISPERSIONS: AN APPROACH TOWARDS ENHANCING DISSOLUTION RATE. Kalia, Anupama; Poddar, Mayur // International Journal of Pharmacy & Pharmaceutical Sciences;Oct2011, Vol. 3 Issue 4, p9 

    A success of formulation depends on how efficiently it makes the drug available at the site of action. Among all the newly discovered chemical entities, about 40-45% drugs fail to reach market due to their poor water solubility. Because of solubility problem, bioavailability of drugs gets...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics