TITLE

Antidiabetic activity of Madhumega Churanam (Siddha formulation) in alloxan induced diabetic rats

AUTHOR(S)
Vadivelan, R.; Umasankar, P.; Dipanjan, M.; Dhanabal, S. P.; Shanish, A.; Satishkumar, M. N.; Elanko, K.
PUB. DATE
April 2011
SOURCE
Der Pharmacia Sinica;2011, Vol. 2 Issue 2, p299
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present study was performed to evaluate Siddha formulation for its antidiabetic activity in alloxan (120 mg/kg, i.p.) induced diabetic rats. The effects of Siddha formulation on fasting blood glucose level, body weight, fluid intake cholesterol and triglyceride were studied. Siddha formulation (100 mg/kg/day and 200 mg/kg/day p.o.) was administered to a group of diabetic rats (n=6) for 14 consecutive days and the observed data was compared with glibenclamide (10 mg/ kg/ day p.o.). Administration of churanam causes a significant reduction of blood glucose level (p< 0.001), body weight (p<0.001), fluid intake levels (p<0.001), cholesterol (p<0.001) and triglycerides (p<0.001), vs diabetic control. It can be concluded from the present study that oral administration of Siddha formulation (Madhumega churanam) ameliorated the plasma glucose and lipid levels in alloxan- induced diabetic rats.
ACCESSION #
64287777

 

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