October 2011
Pakistan Journal of Pharmaceutical Sciences;Oct2011, Vol. 24 Issue 4, p565
Academic Journal
Garlic has been used safely since ancient times as both food and medicine in human populations, but studies of its efficacy in the management of diabetes have yielded conflicting results. This study has evaluated the potential hypoglycemic effects of garlic in type 2 diabetic patients. The study was conducted in diagnosed type 2 diabetic patients (n=60) with fasting blood sugar level above 126 mg/dl to evaluate the effects of adding garlic tablets with standard antidiabetic therapy on blood sugar. Patients were divided randomly into 2 groups. Group 1 (n=30) was given tablet Garlic (KWAI) 300 mg thrice daily + Metformin 500 mg twice daily and Group 2 (n=30) was given Placebo+Metformin 500 mg twice daily respectively for 24 weeks. Serum lipids and fasting blood glucose were measured at week 0, 12 and week 24. Group l showed significant reduction in fasting blood sugar at week 24 with a percentage decrease of (-3.12 percent) (P = <0.005) as compared to group 2 (0.59 percent). At the end of week 24, GRI group also showed considerable decrease in mean total cholesterol (6.2 mg/dl, -2.82%, P=<0.005), LDL-C (-3 mg/dl, 2.18% P=<0.005), triglycerides (-5.2 mg/dl, 3.12%, P<0.005) while HDL cholesterol was significantly increased (2.36 mg/dl, 6.72%, P<0.005) as compared to GR2 group. Combination of garlic with typical antidiabetic remedy has shown to improve glycemic control in addition to antihyperlipidemic activity. Garlic may be a good addition in the management of patients with diabetes and hyperlipidemia.


Related Articles

  • Jerusalem artichoke tubers, Onion and Hulless barley as Functional Foods in Alloxan Induced Diabetic Rats. Al Safwat, H.; Sarwat, Mostafa I.; El-Tobgy, Kareem M. K.; Abd El Alem, Marwa S. // Journal of Applied Sciences Research;Feb2012, Vol. 8 Issue 2, p1328 

    The present study aimed to evaluate the biochemical parameter of diabetic rats fed on some functional foods (Jerusalem artichoke tuber, Onion and Hulless barley). Insulin hormone, glucose level, total cholesterol and triglycerides in diabetic rat serum were estimated. The obtained results...

  • Anti-diabetic activity of polysaccharides from Agaricus bisporus mycelia. Zhou Taoying; Li Xingyuan; Chen Nianyou; Wang Zilin; Yu Liangbin; Yang Huide; Bi Yu // Advanced Materials Research;2014, Vol. 1073-1076, p1808 

    The present study was carried out to evaluate the anti-diabetic activity of polysaccharides from Agaricus bisporus mycelia (PABM) in alloxan-induced diabetes mellitus (DM) mice. After administration with 100, 200 and 400 mg/kg body weight of PABM to DM mice for 28 days, the effects of PABM on...

  • Using Hemoglobin A1C as a Predicting Model for Time Interval from Pre-Diabetes Progressing to Diabetes. Huang, Chen-Ling; Iqbal, Usman; Nguyen, Phung-Anh; Chen, Zih-Fang; Clinciu, Daniel L.; Hsu, Yi-Hsin Elsa; Hsu, Chung-Huei; Jian, Wen-Shan // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Objective: The early identification of subjects at high risk for diabetes is essential, thus, random rather than fasting plasma glucose is more useful. We aim to evaluate the time interval between pre-diabetes to diabetes with anti-diabetic drugs by using HbA1C as a diagnostic tool, and...

  • Antidiabetic properties of S-allyl cysteine, a garlic component on streptozotocin-induced diabetes in rats. Saravanan, Ganapathy; Ponmuruga, Ponnusamy; Kumar, Gandhipuram Periasamy Senthil; Rajarajan, Thatchinamoorthi // Journal of Applied Biomedicine (De Gruyter Open);Sep2009, Vol. 7 Issue 3, p151 

    The present study was carried out to investigate the hypoglycaemic effect of S-allyl cysteine (SAC), a garlic component, on some biochemical parameters of STZ induced diabetic rats. STZ induced diabetic rats were treated with SAC at two different doses (100 mg/kg b.w. and 150 mg/kg b.w.) for 45...

  • HYPOGLYCEMIC EFFECT OF METHANOLIC EXTRACT OF BERBERIS ARISTATA DC STEM ON NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS. Upwar, Nitinkumar; Patel, Roshan; Waseem, Naheed; Mahobia, Naveen Kumar // International Journal of Pharmacy & Pharmaceutical Sciences;Jan2011, Vol. 3 Issue 1, p222 

    Berberis aristata DC (Berberidaceae) is used in Indian traditional medicine for treating antibacterial, antiperiodic, antidiarrhoeal, ophthalmic, skin diseases and diabetes mellitus. Objective of this study is to induce experimental diabetes mellitus using streptozotocin in normal adult male...

  • Pioglitazone Decreases Fasting and Postprandial Endogenous Glucose Production in Proportion to Decrease in Hepatic Triglyceride Content. Ravikumar, Balasubramanian; Gerrard, Jean; Man, Chiara Dalla; Firbank, Michael J.; Lane, Annette; English, Philip T.; Cobelli, Claudio; Taylor, Roy // Diabetes;Sep2008, Vol. 57 Issue 9, p2288 

    OBJECTIVE--Hepatic triglyceride is closely associated with hepatic insulin resistance and is known to be decreased by thiazolididinediones. We studied the effect of pioglitazone on hepatic triglyceride content and the consequent effect on postprandial endogenous glucose production (EGP) in type...

  • FGF-21 Regulates the Metabolic State of Diabetic Monkeys. Kharitonenkov, Alexei; Wroblewski, Victor J.; Koester, Anja; Chen, Yun-Fei; Clutinger, Cathleen K.; Shanafelt, Armen B.; Etgen, Garret J.; Tigno, Xenia T.; Hansen, Barbara C. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA668 

    FGF-21 has been recently characterized as a potent metabolic regulator. Systemic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in genetically compromised diabetic rodents. Importantly, these effects were durable and did not come at the expense of weight...

  • Antidiabetic Effect of Essential Oil from Artemisia sieberi Growing in Jordan in Normal and Alloxan Induced Diabetic Rats. Irshaid, F.; Mansi, K.; Aburjai, T. // Pakistan Journal of Biological Sciences;2010, Vol. 13 Issue 9, p423 

    The aim of this study was to evaluate the effects of essential oil extracted from aerial parts of Artemisia sieberi in normal and alloxan induced diabetic rats. Fifty rats were divided into five groups of 10 each. Group I normal rats received 1 mL day-1 of dimethyl sulfoxide (control); group II...

  • Cdk5-dependent regulation of glucose-stimulated insulin secretion. Fan-Yan Wei; Nagashima, Kazuaki; Ohshima, Toshio; Saheki, Yasunori; Yun-Fei Lu; Matsushita, Masayuki; Yamada, Yuichiro; Mikoshiba, Katsuhiko; Seino, Yutaka; Matsui, Hideki; Tomizawa, Kazuhito // Nature Medicine;Oct2005, Vol. 11 Issue 10, p1104 

    Tight glycemic control in individuals with diabetes mellitus is essential to prevent or delay its complications. Present treatments to reduce hyperglycemia mainly target the ATP-sensitive K+ (KATP) channel of pancreatic beta cells to increase insulin secretion. These current approaches are often...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics