A Human T-Lymphotropic Retrovirus (HTLV-III) as the Cause of the Acquired Immunodeficiency Syndrome

Gallo, Robert C.; Wong-Staal, Flossie
November 1985
Annals of Internal Medicine;Nov85, Vol. 103 Issue 5, p679
Academic Journal
Examines the virus that causes AIDS. Biological features of retroviruses; Structure of retroviral genomes; Morphology of the target cell of human retroviruses.


Related Articles

  • Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolution. Hughes, Jennifer F.; Coffin, John M. // Nature Genetics;Dec2001, Vol. 29 Issue 4, p487 

    Human endogenous retroviruses (HERVs), which are remnants of past retroviral infections of the germline cells of our ancestors, make up as much as 8% of the human genome and may even outnumber genes. Most HERVs seem to have entered the genome between 10 and 50 million years ago, and they...

  • An HIV Protein Plays a Surprising Role in Gene Activation. T., Raha; Cheng S.W.G.; M.R., Green // PLoS Biology;Feb2005, Vol. 3 Issue 2, p1 

    The article reports that retroviruses are expert manipulators when it comes to coopting their host's cellular resources. A great deal of human complexity stems from the vast repertoire of proteins and mechanisms dedicated to the business of regulating gene expression, and retroviruses like HIV...

  • Cross-Species Transmission and Differential Fate of an Endogenous Retrovirus in Three Mammal Lineages. Zhuo, Xiaoyu; Feschotte, Cédric // PLoS Pathogens;11/12/2015, Vol. 11 Issue 11, p1 

    Endogenous retroviruses (ERVs) arise from retroviruses chromosomally integrated in the host germline. ERVs are common in vertebrate genomes and provide a valuable fossil record of past retroviral infections to investigate the biology and evolution of retroviruses over a deep time scale,...

  • Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: implications for gene therapy. Themis, M.; May, D.; Coutelle, C.; Newbold, R.F. // Gene Therapy;Sep2003, Vol. 10 Issue 19, p1703 

    Attenuated retroviruses are currently the most widely used vectors in clinical gene therapy because of their potential to effect stable and permanent gene transfer. Since gene delivery is accompanied by random insertion of foreign genetic material into the recipient chromosomal DNA, the...

  • A rapid screening procedure for the identification of high-titer retrovirus packaging clones. Murdoch, B; Pereira, D S; Wu, X; Dick, J E; Ellis, J // Gene Therapy;Jul97, Vol. 4 Issue 7, p744 

    We have developed a viral RNA (vRNA) dot blot assay for rapid identification of high-titer retrovirus vector production by packaging cell clones. The procedure employs Trizol LS reagent to purify vRNA from packaging cell supernatants, a sensitive dot blot assay, and PhosphorImager technology to...

  • Functional Genomics Reveals Relationships Between the Retrovirus-Like Ty1 Element and Its Host Saccharomyces cerevisiae. Griffith, Jacqulyn L.; Coleman, Laura E.; Raymond, Adam S.; Goodson, Summer G.; Pittard, William S.; Circe Tsui; Devine, Scott E. // Genetics;Jul2003, Vol. 164 Issue 3, p867 

    Retroviruses and their relatives, the long terminal repeat (LTR) retrotransposons, carry out complex life cycles within the cells of their hosts. We have exploited a collection of gene deletion mutants developed by the Saccharomyces Genome Deletion ProJect to perform a functional genomics screen...

  • Genome-Wide Characterization of Endogenous Retroviruses in Bombyx mori Reveals the Relatives and Activity of env Genes. Min Feng; Xiong Wang; Feifei Ren; Nan Zhang; Yaohong Zhou; Jingchen Sun // Frontiers in Microbiology;8/3/2018, p1 

    Endogenous retroviruses (ERVs) are retroviral sequences that remain fixed in the host genome, where they could play an important role. Some ERVs have been identified in insects and proven to have infectious properties. However, no information is available regarding Bombyx mori ERVs (BmERVs) to...

  • Endogenous retroviruses. Blikstad, V.; Benachenhou, F.; Sperber, G. O.; Blomberg, J. // Cellular & Molecular Life Sciences;Nov2008, Vol. 65 Issue 21, p3348 

    Endogenous retroviruses (ERVs) most likely are remnants of ancient retroviral infections. ERVs preserve functions of exogenous retroviruses to a varying extent, and can be parasites, symbionts or more or less neutral genetic ‘junk’.Their evolution has two facets, pre- and...

  • Endogenous retroviruses. Stocking, C.; Kozak, C. A. // Cellular & Molecular Life Sciences;Nov2008, Vol. 65 Issue 21, p3383 

    Up to 10% of the mouse genome is comprised of endogenous retrovirus (ERV) sequences, and most represent the remains of ancient germ line infections. Our knowledge of the three distinct classes of ERVs is inversely correlated with their copy number, and their characterization has benefited from...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics