TITLE

Humanized mice for the study of type 1 and type 2 diabetes

AUTHOR(S)
Greiner, Dale L.; Brehm, Michael A.; Hosur, Vishnu; Harlan, David M.; Powers, Alvin C.; Shultz, Leonard D.
PUB. DATE
December 2011
SOURCE
Annals of the New York Academy of Sciences;Dec2011, Vol. 1245 Issue 1, p55
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.
ACCESSION #
70018149

 

Related Articles

  • Treating Type 2 Diabetes Mellitus: A Growing Epidemic. Weinstock, Ruth S. // Mayo Clinic Proceedings;Apr2003, Vol. 78 Issue 4, p411 

    Editorial. Introduces articles published in the April 2003 issue of 'Mayo Clinic Proceedings' journal. Treatment of type-2 diabetes mellitus. Prevalence; Importance of early diagnosis for the initiation of aggressive treatment to prevent complications; Glycemic control; Insulin resistance.

  • MULBERRY NATURALLY AIDS BLOOD SUGAR CONTROL. Kiefer, Dale // Life Extension;Sep2004, Vol. 10 Issue 9, p31 

    Explains that mulberry leaves contain substances that reverse insulin resistance. Study in India involving patients with type II diabetes; Observation that patients taking mulberry leaves had significantly lower fasting glucose; Statistically insignificant effect of glibenclamide.

  • Short Insulin Tolerance Test May Determine Thiazolidinediones Treatment in Type 2 Diabetes. Lee, Mi Y.; Koh, Jang H.; Jung, Pil M.; Shim, Myoung S.; Kim, Mi J.; Shin, Jang Y.; Shin, Young G.; Chung, Choon H. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA578 

    The short insulin tolerance test is a simple and reliable method of estimating insulin sensitivity. This study was designed to compare the insulin sensitizing effects of thiazolidinediones (TZDs) on the degree of insulin resistance determined by short insulin tolerance test, Kitt in type 2...

  • Novel Polysaccharide H-1-2 from Pseudostellaria Heterophylla Alleviates Type 2 Diabetes Mellitus. Zhao-hui Fang; Xian-chun Duan; Jin-dong Zhao; Yuan-jie Wu; Meng-meng Liu // Cellular Physiology & Biochemistry (Karger AG);Oct2018, Vol. 49 Issue 3, p1037 

    Background/Aims: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate the underling molecular mechanisms. Methods: Relative expression of HIF1α and Sirt1 in T2DM patients was...

  • MAP3K8 (TPL2/COT) Affects Obesity-Induced Adipose Tissue Inflammation without Systemic Effects in Humans and in Mice. Ballak, Dov B.; van Essen, Peter; van Diepen, Janna A.; Jansen, Henry; Hijmans, Anneke; Matsuguchi, Tetsuya; Sparrer, Helmut; Tack, Cees J.; Netea, Mihai G.; Joosten, Leo A. B.; Stienstra, Rinke // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Chronic low-grade inflammation in adipose tissue often accompanies obesity, leading to insulin resistance and increasing the risk for metabolic diseases. MAP3K8 (TPL2/COT) is an important signal transductor and activator of pro-inflammatory pathways that has been linked to obesity-induced...

  • Regulation of Insulin Degrading Enzyme Activity by Obesity-Associated Factors and Pioglitazone in Liver of Diet-Induced Obese Mice. Wei, Xiuqing; Ke, Bilun; Zhao, Zhiyun; Ye, Xin; Gao, Zhanguo; Ye, Jianping // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Insulin degrading enzyme (IDE) is a potential drug target in the treatment of type 2 diabetes (T2D). IDE controls circulating insulin through a degradation-dependent clearance mechanism in multiple tissues. However, there is not sufficient information about IDE regulation in obesity. In this...

  • Ileal Effect on Blood Glucose, HbA1c, and GLP-1 in Goto-Kakizaki Rats. Buchwald, Henry; Menchaca, Hector; Michalek, Van; Bertin, Nestor // Obesity Surgery;Nov2014, Vol. 24 Issue 11, p1954 

    Background: There have been enumerable studies on the effects of glucagon-like peptide-1 (GLP-1) on satiety and pancreatic islet function, stimulating the advocacy of surgical transposition of the ileum (rich in GLP-1-generating L-cells) higher in the gastrointestinal tract for earlier...

  • Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System. Lundquist, Ingmar; Mohammed Al-Amily, Israa; Meidute Abaraviciene, Sandra; Salehi, Albert // PLoS ONE;11/7/2016, Vol. 11 Issue 11, p1 

    Metformin lowers diabetic blood glucose primarily by reducing hepatic gluconeogenesis and increasing peripheral glucose uptake. However, possible effects by metformin on beta-cell function are incompletely understood. We speculated that metformin might positively influence insulin secretion...

  • The Relationship between HbA1c, Insulin Resistance and Changes of Insulin Secretion in Indonesian Type 2 Diabetic Subjects. Srihardyastutie A.; Soeatmadji, D. W.; Fatchiyah; Aulanni'am // Advances in Natural & Applied Sciences;Jul2014, Vol. 8 Issue 8, p25 

    Type 2 Diabetes Mellitus (Type 2 DM) is considered as heterogenous metabolic disorder with the common characteristic of elevated blood glucose. The main cause of hyperglycemia in Type 2 DM are impaired of insulin secretion and increased insulin resistance. The HbA1c assay has become the most...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics