Stem Cell Mutations Explored

Luntz, Stephen
March 2012
Australasian Science;Mar2012, Vol. 33 Issue 2, p5
The article discusses a research study on pluripotent stem cells which found that there are higher mutation rates in the induced pluripotent stem cell (iPS) lines as compared with the human embryonic stem (HES) cell lines.


Related Articles

  • TBX3 Promotes Human Embryonic Stem Cell Proliferation and Neuroepithelial Differentiation in a Differentiation Stage-dependent Manner. Esmailpour, Taraneh; Huang, Taosheng // Stem Cells (Wiley-Blackwell);Oct2012, Vol. 30 Issue 10, p2152 

    T-box 3 (Tbx3) is a member of the T-box family of genes. Mutations that result in the haploinsufficiency of TBX3 cause ulnar mammary syndrome in humans characterized by mammary gland hypoplasia as well as other congenital defects. In mice, homozygous mutations are embryonic lethal, suggesting...

  • Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. Bellin, Milena; Casini, Simona; Davis, Richard P; D'Aniello, Cristina; Haas, Jessica; Ward-van Oostwaard, Dorien; Tertoolen, Leon G J; Jung, Christian B; Elliott, David A; Welling, Andrea; Laugwitz, Karl-Ludwig; Moretti, Alessandra; Mummery, Christine L // EMBO Journal;12/11/2013, Vol. 32 Issue 24, p3161 

    Patient-specific induced pluripotent stem cells (iPSCs) will assist research on genetic cardiac maladies if the disease phenotype is recapitulated in vitro. However, genetic background variations may confound disease traits, especially for disorders with incomplete penetrance, such as long-QT...

  • Session 53: Are human embryonic stem cells ready for regenerative medicine?  // Human Reproduction;Jun2013, Vol. 28 Issue suppl_1, pi84 

    No abstract available.

  • Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells. Duggal, Galbha; Warrier, Sharat; Ghimire, Sabitri; Broekaert, Dorien; Van der Jeught, Margot; Lierman, Sylvie; Deroo, Tom; Peelman, Luc; Van Soom, Ann; Cornelissen, Ria; Menten, Björn; Mestdagh, Pieter; Vandesompele, Jo; Roost, Matthias; Slieker, Roderick C.; Heijmans, Bastiaan T.; Deforce, Dieter; De Sutter, Petra; De Sousa Lopes, Susana Chuva; Heindryckx, Björn // Stem Cells (Wiley-Blackwell);Sep2015, Vol. 33 Issue 9, p2686 

    Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state. Efforts have been made to trigger naïve pluripotency in hESCs for subsequent unbiased lineage-specific...

  • Pushing the Reset Button: Chemical-Induced Conversion of Amniotic Fluid Stem Cells Into a Pluripotent State. Diecke, Sebastian; Wu, Joseph C // Molecular Therapy;Oct2012, Vol. 20 Issue 10, p1839 

    The authors discuss the study on the factor-free derivation of a pluripotent cell type using a c-Kit+ subpopulation of human amniotic fluid cells. The authors say that the potential of human embryonic stem cells (hESC) to differentiate into any cell type of the human body has raised the hope on...

  • Putting induced pluripotent stem cells to the test. Vallier, Ludovic // Nature Biotechnology;Nov2015, Vol. 33 Issue 11, p1145 

    The article focuses on the sustainability of Human induced pluripotent stem cells (hiPSCs) for supporting clinical applications. Topics discussed include new possibilities for personalized cell therapy after the discovery that human somatic cell can be reprogrammed into a pluripotent stem cell,...

  • An in vivo model of human small intestine using pluripotent stem cells. Watson, Carey L; Helmrath, Michael A; Mahe, Maxime M; Sundaram, Nambirajan; Poling, Holly M; Múnera, Jorge; Schweitzer, Jamie I; Mayhew, Christopher N; Wells, James M; Howell, Jonathan C; Vallance, Jefferson E; Sun, Ying; Grabowski, Gregory; Finkbeiner, Stacy R; Spence, Jason R; Shroyer, Noah F // Nature Medicine;Nov2014, Vol. 20 Issue 11, p1310 

    Differentiation of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers an exciting avenue for the study of embryonic development and disease processes, for pharmacologic studies and as a potential resource for therapeutic transplant. To date, limited in vivo models exist for...

  • Metabolic Control of Stemness and Differentiation. Moresi, Viviana; Sotiropoulos, Athanassia; Caretti, Giuseppina; Harvey, Alexandra // Stem Cells International;6/12/2019, p1 

    No abstract available.

  • Antibody-Directed Lentiviral Gene Transduction for Live-Cell Monitoring and Selection of Human iPS and hES Cells. Dai-tze Wu; Seita, Yasunari; Xia Zhang; Chi-Wei Lu; Roth, Monica J. // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    The identification of stem cells within a mixed population of cells is a major hurdle for stem cell biology-in particular, in the identification of induced pluripotent stem (iPS) cells during the reprogramming process. Based on the selective expression of stem cell surface markers, a method to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics