TITLE

SWI/SNF Chromatin Remodeling Complex: A New Cofactor in Reprogramming

AUTHOR(S)
He, Ling; Liu, Huan; Tang, Liling
PUB. DATE
March 2012
SOURCE
Stem Cell Reviews & Reports;Mar2012, Vol. 8 Issue 1, p128
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Induced pluripotent stem (iPS) cells can be derived from somatic cells. Four key factors are required in this process including Oct4, Sox2, Klf4 and c-Myc. Ectopic expression of these four factors in somatic cells leads to reprogramming. Recent studies show that the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex plays critical roles in reprogramming of somatic cells and maintaining the pluripotency of stem cells. The possible mechanism is that SWI/SNF enhances the binding activity of reprogramming factors to pluripotent gene promoters and thus increases the reprogramming efficiency. Here, we review these recent advances and discuss how SWI/SNF plays a role in reprogramming. Understanding this mechanism will be helpful to find out the detail of reprogramming, which may provide a new therapy in medical science by generating patient-specific pluripotent stem cells.
ACCESSION #
71925596

 

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