Changes of IL-1, TNF-Alpha, IL-12 and IL-10 Levels with Chronic Liver Failure

Guowang Liu; Kecheng Tang; Qian Li Guiyu Yuan; Wukui Cao; Wei Lu
April 2011
Surgical Science;Apr2011, Vol. 2 Issue 2, p69
Academic Journal
Aim: To investigate the action of cytokines in patients with chronic liver failure and to explore the roles of cytokines in chronic liver failure. Methods: Thirty-one patients with chronic liver failure admitted from May 2006 to November 2009 were included. Thirty cases with mild to moderate chronic type B hepatitis admitted concomitantly were regarded as control. IL-1, TNF-alpha, IL-12, IL-10 Levels in serum was the factors to determine at clinical diagnosis and 2-week treatment. We analyzed levels of cytokines action in 31 chronic liver failure patients both at clinical diagnosis and 2-week treatment in comparison with control group. Results: We analyzed IL-1 level in death group at clinical diagnosis and 2-week treatment were significant higher than in survival and control groups, furthermore it was also higher in survival group than in control group. At clinical diagnosis, TNF-alpha level in death group was higher than that in control. However, there was no obviously difference between the death group and the survival group in TNF-alpha level. With the progression of the disease, TNF-alpha level was remarkably risen in death group, but decreased in survival group. IL-10 level was dramatically increased in death group, but no changed in survival group. IL-12 level in death group was higher than in survival group, but lower than in control group. Conclusions: The levels of TNF-alpha, IL-1, IL-10 and IL-12 in patients with chronic liver failure was increased and the increase of IL-10 is secondary to elevation of IL-12.


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