TITLE

Evaluation of Analgesic and Antidiarrhoeal Effects of Methanolic Extract of Marsilea quadrifolia in rat

AUTHOR(S)
Nahar, Laizuman; Ripa, Farhana Alam; Zahan, Ronok; Bulbul, Israt Jahan; Parvej, Ibrahim
PUB. DATE
December 2011
SOURCE
Journal of Pharmacy Research;Dec2011, Vol. 4 Issue 12, p4374
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of the present study was to evaluate the possible analgesic and antidiarrhoeal potential of methanolic extract of Marsilea quadrifolia (MEMQ) in rats. The analgesic activity was tested by using acetic acid-induced writhing response and formalin test. The methanolic extract of the plant was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil in rat. It was found that the extract caused an inhibition on the writhing response induced by acetic acid in a dose dependent manner. 100 & 200 mg/kg doses of MEMQ and indomethacin could block the writhing response by 60.13%, 72.15% and 58.86% (p<0.001), respectively. It was also observed that the MEMQ significantly (p< 0.05) suppressed the licking activity in either phase of the formalin induced pain in rats. At the doses of 250 and 500 mg/kg per oral, the methanolic extract showed significant (p< 0.001) and dose-dependent antidiarrhoeal activity in both models. The results indicate the potent analgesic and antidiarrhoeal effects of Marsilea quadrifolia extract on animal models which are comparable with those of standard drugs such as Indomethacin, Loperamide respectively and supports its traditional uses as medicine.
ACCESSION #
74296829

 

Related Articles

  • Study of analgesic activity of ethanol extract of Phlogacanthus thyrsiflorus on experimental animal models. Mukherjee, Apurba; Chaliha, Meghali; Das, Swarnamoni // Bangladesh Journal of Pharmacology;Dec2009, Vol. 4 Issue 2, p147 

    The aim of the study was to evaluate the central and peripheral analgesic action of Phlogacanthus thyrsiflorus in experimental animal models. The extract was prepared by percolation method and acute oral toxicity testing was performed as per OECD guidelines. Analgesic activity was assessed by...

  • COMPARISON OF ANTI-DIARRHEAL ACTIVITY OF HYDROETHANOLIC EXTRACTS OF CALOTROPIS PROCERA AND CALOTROPIS GIGANTEA LEAVES. Murti, Yogesh; Singh, Abhay Pratap; Pathak, Devender // Journal of Pharmaceutical & Scientific Innovation;Jul/Aug2012, Vol. 1 Issue 4, p32 

    The 70% hydroethanolic extracts of Calotropis procera (CP) and Calotropis gigantea (CG) leaves have been evaluated and compared for anti-diarrheal activity using castor oil-induced diarrhea model in rats. Results showed statistically significant reduction in the frequency and severity of...

  • Antidiarrheal Activity of Methanolic Extract of Leaves of Gymnosporia Emerginata. Suvarchala Kiranmai, A.; Hemamalini, K.; Sumalatha, P.; Shashi Priya, G.; Vasireddy, Uma // Journal of Applied Pharmaceutical Science;Nov2013, Vol. 3 Issue 11, p143 

    The methanolic leaf extract of Gymnosporia emerginata showed significant antidiarrheal activity on castor oil induced diarrheal model in rats. These results obtained revealed that the leaf extract possess pharmacological activity against diarrhea and may possibly explain the use of the plants in...

  • Experimental evaluation of analgesic property of bark skin of Saraca indica (Ashoka) and Shorea robusta (Shal). Mohod, Poonam S.; Jangde, C. R.; Narnaware, S. D.; Raut, Subhash // GeroFam;Mar2014, Vol. 4 Issue 3, p62 

    The aqueous and alcoholic extracts of bark skin of Saraca indica (Ashoka) and Shorea robusta (Shal) were evaluated for their analgesic activity in Swiss albino rats by making use of different pain models such as, tail immersion test, tail clip method and writhing induced by 4% NaCl solution. The...

  • Evaluation of analgesic activity of Alianthus excelsa Roxb. using rat as an experimental animal. Chauhan, Khushbu; Parmar, Lalkrushn; Solanki, Roshni; Sundariya, Dhruvil; Adeshara, S. P. // Journal of Pharmacy Research;May2011, Vol. 4 Issue 5, p1336 

    Ailanthus excelsa Roxb. is a tree belonging to family Simaroubaceae, commonly known as a plant of Heaven. The bark of the plant is reported for various pharmacological activities including ear ache, aantimicrobial, anti-viral, antitumor, cytotoxic, hypotensive, abortifacient, diabetes mellitus,...

  • DEVELOPMENT AND EVALUATION OF ANALGESIC POLYHERBAL FORMULATION CONTAINING SOME INDIGENOUS MEDICINAL PLANTS. GOMASE, PRAVIN V.; SHIRE, PRITI S.; NAZIM, SAYYED; CHOUDHARI, AMOL B. // International Journal of Pharma & Bio Sciences;Jul-Sep2011, Vol. 2 Issue 3, pP.119 

    The present study explores the Polyherbal formulation for Analgesic activity of ethanolic leaves extracts of Momardica charantia Linn and Azadirachta indica A. Juss agaist experimental model of Eddy's hot plate method And Heat conduction method response in rats. The effective dose of the extract...

  • Chemical composition and antinociceptive effects of essential oil from aerial parts of Gundelia tournefortii L Asteraceae (Compositae) in rats. Qnais, Esam; Bseiso, Yousra; Wedyan, Mohammad; Al-Omari, Maryam; Alkhateeb, Hakam // Tropical Journal of Pharmaceutical Research;Oct2016, Vol. 15 Issue 10, p2183 

    Purpose: To investigate the antinociceptive effect of the essential oil from the aerial parts of Gundelia. tournefortii (EOGT) in various experimental models. Methods: The essential oil from the aerial parts of Gundelia tournefortii was extracted using steam distillation method median lethal...

  • The Effect of Berchemia berchemiaefolia Extract in a Rat Model Acetic Acid-induced Irritable Bowel Syndrome. Gilhyun Lee; Junseon Lee; Miha Joo; Seokcheol Choi; Kyungyae Hyun // International Journal of Bio-Science & Bio-Technology;2014, Vol. 6 Issue 5, p67 

    This study was conducted to reveal medicinal effect of Berchemia berchemiaefolia (BB) extract for induced IBS-rat model. IBS was induced by injecting acetic acid into target of Spraque-Dawley rats' colon. Control group and experimental group were categorized as follows; Group I: control group...

  • Analgesic and antipyretic activities of Curcuma longa rhizome extracts in Wister Rats. Neha, S.; Ranvir, G. D.; Jangade, C. R. // Veterinary World;Aug2009, Vol. 2 Issue 8, p304 

    The study was carried out to ascertain analgesic and antipyretic activities of rhizome extracts of Curcuma longa in Wister rats. Both aqueous and alcoholic extracts at 100 and 200 mg/kg by oral, single dose treatment for seven days revealed significant difference (P<0.05, 0.01) in reaction time...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics