Kaur, Jatinder; Aggarwal, Geeta; Singh, Gurpreet; Rana, A.C.
March 2012
International Journal of Pharmacy & Pharmaceutical Sciences;Mar2012, Vol. 4 Issue 2, p47
Academic Journal
The solubility behaviour of drug is one of the most challenging aspects in formulation development. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water soluble drugs, one of such approach is using different solid dispersion techniques. This article reports different types of solid dispersion, various solubility enhancement strategies in solid dispersion, advantages of solid dispersion over other techniques and applications of solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extruding method, spray drying technology, use of surfactant, electro static spinning method and super critical fluid technology.


Related Articles

  • Supercritical fluid technology: A promising approach to enhance the drug solubility. Thakkar, Furqan Maulvi V. T.; Soni, T. G.; Gohel, M. C.; Gandhi, T. R. // Journal of Pharmaceutical Sciences & Research;Dec2009, Vol. 1 Issue 4, p1 

    The article presents a study on the approach towards the enhancement of drug solubility. It mentions that the key determinant in oral bioavailability and the rate-limiting in the absorption of drugs from the gastrointestinal tract are the solubility or dissolution behavior of a drug. It notes...

  • SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF VALSARTAN IN BULK AND ORAL DOSAGE FORM. Kalaimagal, A.; Jerad Suresh, A.; Niraimathi, V. // International Journal of Pharmacy & Pharmaceutical Sciences;Mar2012, Vol. 4 Issue 2, p481 

    Simple precise UV spectrophotometric methods have been developed for the estimation of Valsartan in both bulk and tablet dosage form. Valsartan is well soluble in sodium hydroxide and shows maximum absorption at 249nm. The drug obeyed Beer's law showing linearity in the range of 5- 30μg/ml...

  • FABRICATION AND EVALUATION OF METFORMIN HCL TABLETS USING NATURAL POLYMERS AND EXCIPIENTS. MATHEW, A. M.; KASLIWAL, R. H. // International Journal of Pharma & Bio Sciences;Oct-Dec2013, Vol. 4 Issue 4, pP-218 

    The oral route of administration of drugs is the most important method for achieving systemic effects. In the process of absorption of drug from oral route dissolution is the rate limiting step. Since the drug belongs to BCS class III, it is necessary to retard dissolution to ensure extended...

  • Uticaj podloge na otpuÅ¡tanje antibiotika iz lekovitih masti. Toskić-Radojičić, Marija; Nonković, Zorka // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;May2005, Vol. 62 Issue 5, p383 

    Background. Officinal basis for the antibiotic ointments according to the 4th Yugoslav Pharmacopoeia is a hydrophobic base containing only aliphatic hydrocarbons. The fact that antibiotics are predominantly not lipophylic raises the question about the suitability of that particular type of the...

  • Review of Current Issues in Pharmaceutical Excipients. Chang, Dorothy; Rong-Kun Chang // Pharmaceutical Technology;May2007, Vol. 31 Issue 5, p56 

    The article examines some of the important issues on pharmaceutical excipients, industry trends in using pharmaceutical additives and basic principles of formulation design. The reasons why fewer ingredients in the formulation are better are listed. It is said that paying attention to...

  • Automated signal generation in prescription-event monitoring. Heeley, E.; Wilton, L.V.; Shakir, S.A.W.; Heeley, Emma; Wilton, Lynda V; Shakir, Saad A W // Drug Safety;Apr2002, Vol. 25 Issue 6, p423 

    Signal generation is a method of highlighting potential safety issues in a drug that then need to be investigated further. Previously automated signal generation has mainly been applied to spontaneous reporting systems. The Drug Safety Research Unit (DSRU) performs observational postmarketing...

  • CPL Contract Pharmaceuticals Limited.  // Pharmaceutical Technology;Dec2008 Supplement, p108 

    The article profiles Contract Pharmaceuticals Ltd. (CPL) in Mississauga, Ontario. The company is the leader in manufacturing, packaging, and analytical testing of prescription and over-the-counter pharmaceutical. It builds long-term relationships to customers based on trust and excellence in the...

  • Multifunctional Excipients: Creating new possibilities. Patel, Ashok // Contract Pharma;Nov/Dec2009, Vol. 11 Issue 9, p62 

    The article focuses on the use of multifunctional excipients in the drug formulation process. It notes how multifunctional excipients obtained or developed, as well as the applications and benefits of multifunctional excipients. It cites some of the multifunctional excipients which are already...

  • PARTICLE SIZE DETERMINATION OF NASAL DRUG DELIVERY SYSTEM: A REVIEW. Sangolkar, Sunil S.; Adhao, Vaibhav S.; Mundhe, Dinkar G.; Sawarkar, Harigopal S. // International Journal of Pharmaceutical Sciences Review & Resear;Nov/Dec2012, Vol. 17 Issue 1, p66 

    Until quite recently nasal delivery of pharmaceutical formulations was confined largely to locally acting therapeutics such as decongestants and antihistamines. Today though, the nasal route is receiving considerable attention for administering drugs that net systemically. The opportunity for...


Other Topics