TITLE

Heat-Denatured Human Immunodeficiency Virus Type 1 Protein 24 Antigen: Prognostic Value in Adults with Early-Stage Disease

AUTHOR(S)
Sterling, Timothy R.; Hoover, Donald R.; Astemborski, Jacquie; Vlahov, David; Bartlett, John G.; Schupbach, Jorg
PUB. DATE
October 2002
SOURCE
Journal of Infectious Diseases;10/15/2002, Vol. 186 Issue 8, p1181
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
CD4[SUP+] lymphocyte count and human immunodeficiency virus (HIV) type 1 RNA level are useful for determining when to initiate antiretroviral therapy but are not used widely in developing countries due to the high cost. Heat-denatured protein 24 (p24) antigen is an inexpensive assay that predicts disease progression among persons with advanced disease but has not been assessed among persons with early-stage disease. Plasma levels of heat-denatured p24 antigen were quantified in baseline study-visit specimens obtained from injection drug users enrolled in a longitudinal cohort study of HIV-1 infection. Of the 494 study participants (median initial CD4[SUP+] lymphocyte count, 518 lymphocytes/mm[SUP3]), 90 (18%) progressed to acquired immunodeficiency syndrome within 5 years, p24 antigen level correlated with both CD4[SUP+] lymphocyte count (r = -0.34; P < .0001) and HIV-1 RNA level (r = 0.55; P < .0001). p24 antigen level >5 pg/mL predicted disease progression, comparable with that of cutoff CD4[SUP+] lymphocyte count <350 lymphocytes/mm[SUP3] and HIV-1 RNA level >30,000 copies/mL. Heat-denatured p24 antigen level predicted subsequent clinical disease progression in early-stage HIV-1 infection and correlated with both CD4[SUP+] lymphocyte count and HIV-1 RNA level.
ACCESSION #
7596920

 

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