TITLE

DRhigh+CD45RA--Tregs Potentially Affect the Suppressive Activity of the Total Treg Pool in Renal Transplant Patients

AUTHOR(S)
Schaier, Matthias; Seissler, Nicole; Schmitt, Edgar; Meuer, Stefan; Hug, Friederike; Zeier, Martin; Steinborn, Andrea
PUB. DATE
March 2012
SOURCE
PLoS ONE;Mar2012, Vol. 7 Issue 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Recent studies show that regulatory T cells (Tregs) play an essential role in tolerance induction after organ transplantation. In order to examine whether there are differences in the composition of the total CD4+CD127low+/-FoxP3+-Treg cell pool between stable transplant patients and patients with biopsy proven rejection (BPR), we compared the percentages and the functional activity of the different Treg cell subsets (DRhigh+CD45RA--Tregs, DRlow+CD45RA--Tregs, DR-CD45RA--Tregs, DR-CD45RA+-Tregs). All parameters were determined during the three different periods of time after transplantation (0-30 days, 31-1,000 days, >1,000 days). Among 156 transplant patients, 37 patients suffered from BPR. The most prominent differences between rejecting and non-rejecting patients were observed regarding the DRhigh+CD45RA--Treg cell subset. Our data demonstrate that the suppressive activity of the total Treg pool strongly depends on the presence of these Treg cells. Their percentage within the total Treg pool strongly decreased after transplantation and remained relatively low during the first year after transplantation in all patients. Subsequently, the proportion of this Treg subset increased again in patients who accepted the transplant and reached a value of healthy non-transplanted subjects. By contrast, in patients with acute kidney rejection, the DRhigh+CD45RA--Treg subset disappeared excessively, causing a reduction in the suppressive activity of the total Treg pool. Therefore, both the monitoring of its percentage within the total Treg pool and the monitoring of the HLA-DR MFI of the DR+CD45RA--Treg subset may be useful tools for the prediction of graft rejection.
ACCESSION #
77586073

 

Related Articles

  • DRhigh+CD45RA--Tregs Potentially Affect the Suppressive Activity of the Total Treg Pool in Renal Transplant Patients. Schaier, Matthias; Seissler, Nicole; Schmitt, Edgar; Meuer, Stefan; Hug, Friederike; Zeier, Martin; Steinborn, Andrea // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Recent studies show that regulatory T cells (Tregs) play an essential role in tolerance induction after organ transplantation. In order to examine whether there are differences in the composition of the total CD4+CD127low+/-FoxP3+-Treg cell pool between stable transplant patients and patients...

  • Humoral rejection of human organ transplants. Michaels, Paul J.; Fishbein, Michael C.; Colvin, Robert B. // Springer Seminars in Immunopathology;Sep2003, Vol. 25 Issue 2, p119 

    Although T-cell mediated rejection has remained the most common form of acute rejection, humoral rejection now accounts for a substantial fraction in patients with kidney or heart allografts, and probably causes the majority of acute graft losses. The frequency, variously estimated at 20-30%, is...

  • Liver Grafts Overcome Tissue Rejection in Rat.  // Quintessence International;Jul1982, Vol. 13 Issue 7, p758 

    The article focuses on the exceptional case of tissue acceptance in case of liver transplants. In the transplantation of tissues from one individual to another, the recipient body normally rejects the new tissue or any further grafts. But immunologists at the ARC Institute of Animal Physiology...

  • Evaluation of the highly sensitized transplant recipient. Stastny, Peter; Salvador, Ian-Michael; Lavingia, Bhavna // Pediatric Nephrology;Nov2011, Vol. 26 Issue 11, p1927 

    The immune response against alloantigens involves the production of antibodies and development of T-cell immunity. Recipients sensitized to HLA antigens may have antibodies to almost all donors and may not be able to find a suitable kidney transplant donor. Strategies available to enable these...

  • The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection. Gras, Stephanie; Kjer-Nielsen, Lars; Chen, Zhenjun; Rossjohn, Jamie; McCluskey, James // Immunology & Cell Biology;Mar2011, Vol. 89 Issue 3, p388 

    αβ T-cell receptors (TCRs), which can engage a broad array of foreign peptide-laden major histocompatibility complex (pMHC) landscapes, have an essential role in protective immunity. TCRs are selected by pMHC molecules in the thymus and in the periphery, and so are restricted to...

  • Management of Acute Rejection in Paediatric Liver Transplantation. Thangarajah, D.; O’Meara, M.; Dhawan, A. // Pediatric Drugs;Dec2013, Vol. 15 Issue 6, p459 

    The success of paediatric liver transplantation is attributed to improved surgical techniques and the advent of calcineurin inhibitor-based immunosuppression. Acute rejection (AR) rarely results in graft loss with calcineurin inhibitor immunosuppressive regimens, and the advent of newer agents...

  • Prolonged lymphopenia following anti-thymocyte globulin induction is associated with decreased long-term graft survival in liver transplant recipients. Vrochides, D.; Hassanain, M.; Metrakos, P.; Tchervenkov, J.; Barkun, J.; Chaudhury, P.; Cantarovich, M.; Paraskevas, S. // Hippokratia;Jan2012, Vol. 16 Issue 1, p66 

    Background and aim: Induction with anti-thymocyte globulin (ATG) during solid organ transplantation is associated with an improved clinical course and leads to prolonged lymphopenia. This study aims to investigate whether prolonged lymphopenia, caused by ATG induction, has an impact on patient...

  • Tolerance-Inducing Immunosuppressive Strategies in Clinical Transplantation: An Overview. Golshayan, Dela; Pascual, Manuel // Drugs;2008, Vol. 68 Issue 15, p2113 

    The significant development of immunosuppressive drug therapies within the past 20 years has had a major impact on the outcome of clinical solid organ transplantation, mainly by decreasing the incidence of acute rejection episodes and improving short-term patient and graft survival. However,...

  • Regulating rejection with cell therapy. Sayegh, Mohamed H.; Weiner, Howard L. // Nature Biotechnology;Feb2008, Vol. 26 Issue 2, p191 

    The article discusses a study which shows that regulatory T cells (Tregs) can be used to prevent subsequent acute and chronic allograft rejection of tissues and solid transplants in a donor-specific manner in mice. In the paper, published in the journal "Nature Medicine," researchers also showed...

Share

Read the Article

Other Topics