Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy: A Randomized Controlled Trial

Paton, Nicholas I.; Goodall, Ruth L.; Dunn, David T.; Franzen, Samuel; Collaco-Moraes, Yolanda; Gazzard, Brian G.; Williams, Ian G.; Fisher, Martin J.; Winston, Alan; Fox, Julie; Orkin, Chloe; Herieka, Elbushra A.; Ainsworth, Jonathan G.; Post, Frank A.; Wansbrough-Jones, Mark; Kelleher, Peter
July 2012
JAMA: Journal of the American Medical Association;7/25/2012, Vol. 308 Issue 4, p353
Academic Journal
The article presents a study focusing on the effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy. The results of the study show that among HIV-infected patients not taking antiretroviral therapy, the use of hydroxychloroquine in comparison to placebo did not reduce CD8 cell activation, however it resulted in a greater decline in CD4 cell count and increased viral replication. It also showed that trial medication was well tolerated in patients however more patients reported influenza-like illness in the hydroxychloroquine group.


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