TITLE

Stem cells: Neural progenitors from fibroblasts

PUB. DATE
August 2012
SOURCE
Nature Methods;Aug2012, Vol. 9 Issue 8, p781
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article offers information a research regarding the generation of differentiating pluripotent stem cells of both mouse and human from fibroblasts using a single transcription factor.
ACCESSION #
78164328

 

Related Articles

  • Chromatin-modifying enzymes as modulators of reprogramming. Onder, Tamer T.; Kara, Nergis; Cherry, Anne; Sinha, Amit U.; Zhu, Nan; Bernt, Kathrin M.; Cahan, Patrick; Marcarci, B. Ogan; Unternaehrer, Juli; Gupta, Piyush B.; Lander, Eric S.; Armstrong, Scott A.; Daley, George Q. // Nature;3/29/2012, Vol. 483 Issue 7391, p598 

    Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic states of cells before and after reprogramming, the role of specific...

  • Sirtuin 1 Facilitates Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts through the miR-34a and p53 Pathways. Yin Lau Lee; Qian Peng; Sze Wan Fong; Chen, Andy C. H.; Kai Fai Lee; Ng, Ernest H. Y.; Nagy, Andras; Yeung, William S. B.; Pant, Aditya Bhushan // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Forced-expression of transcription factors can reprogram somatic cells into induced pluripotent stem cells (iPSC). Recent studies show that the reprogramming efficiency can be improved by inclusion of small molecules that regulate chromatin modifying enzymes. We report here that sirtuin 1...

  • Neural Stem Cells Achieve and Maintain Pluripotency without Feeder Cells. Hyun Woo Choi; Jong Soo Kim; Sol Choi; Hyo Jin Jang; Min Jung Kim; Youngsok Choi; Schöler, Hans R.; Hyung Min Chung; Jeong Tae Do // PLoS ONE;2011, Vol. 6 Issue 6, p1 

    Background: Differentiated cells can be reprogrammed into pluripotency by transduction of four defined transcription factors. Induced pluripotent stem cells (iPS cells) are expected to be useful for regenerative medicine as well as basic research. Recently, the report showed that mouse embryonic...

  • Generation of induced pluripotent stem cells from bovine embryonic fibroblast cells. Han, Xiaoping; Han, Jianyong; Ding, Fangrong; Cao, Suying; Lim, Seong Soo; Dai, Yunping; Zhang, Ran; Zhang, Yurui; Lim, Bing; Li, Ning // Cell Research;Oct2011, Vol. 21 Issue 10, p1509 

    The article presents a research study concerning the development of induced pluripotent stem (iPS) cells from bovine embryonic fibroblast cells utilizing defined transcription factors. It notes that the study has been successful wherein the researchers were able to generate iPS cells from bovine...

  • Muse cells and induced pluripotent stem cell: implication of the elite model. Kitada, Masaaki; Wakao, Shohei; Dezawa, Mari // Cellular & Molecular Life Sciences;Nov2012, Vol. 69 Issue 22, p3739 

    Induced pluripotent stem (iPS) cells have attracted a great deal attention as a new pluripotent stem cell type that can be generated from somatic cells, such as fibroblasts, by introducing the transcription factors Oct3/4, Sox2, Klf4, and c-Myc. The mechanism of generation, however, is not fully...

  • Direct conversion in the heart: a simple twist of fate. DeWitt, Natalie D; Trounson, Alan // EMBO Journal;5/16/2012, Vol. 31 Issue 10, p2244 

    No abstract available.

  • Selection of Reprogramming Factors of Induced Pluripotent Stem Cells Based on the Protein Interaction Network and Functional Profiles. Tao Huang; Yu-Dong Cai; Lei Chen; Le-Le Hu; Xiang-Yin Kong; Yi-Xue Li; Kuo-Chen Chou // Protein & Peptide Letters;Jan2012, Vol. 19 Issue 1, p113 

    Induced pluripotent stem cells have displayed great potential in disease investigation and drug development applications. However, selection of reprogramming factors in each cell type or disease state is both expensive and time consuming. To deal with this kind of situation, a fast computational...

  • Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4. Nemajerova, A; Kim, S Y; Petrenko, O; Moll, U M // Cell Death & Differentiation;Aug2012, Vol. 19 Issue 8, p1268 

    Ectopic expression of defined sets of transcription factors in somatic cells enables them to adopt the qualities of pluripotency. Mouse embryonic fibroblasts (MEFs) are the classic target cell used to elucidate the core principles of nuclear reprogramming. However, their phenotypic and...

  • Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1. Moon, Jai-Hee; Heo, June Seok; Kim, Jun Sung; Jun, Eun Kyoung; Lee, Jung Han; Kim, Aeree; Kim, Jonggun; Whang, Kwang Youn; Kang, Yong-Kook; Yeo, Seungeun; Lim, Hee-Joung; Han, Dong Wook; Kim, Dong-Wook; Oh, Sejong; Yoon, Byung Sun; Schöler, Hans R; You, Seungkwon // Cell Research;Sep2011, Vol. 21 Issue 9, p1305 

    Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by the transcription factors Oct4, Sox2, and Klf4 in combination with c-Myc. Recently, Sox2 plus Oct4 was shown to reprogram fibroblasts and Oct4 alone was able to reprogram mouse and human neural stem cells (NSCs) into...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics