Induced pluripotent stem cells in research and therapy

Hoon-Koon Teoh; Soon-Keng Cheong
June 2012
Malaysian Journal of Pathology;Jun2012, Vol. 34 Issue 1, p1
Academic Journal
Induced pluripotent stem cells (iPSC) are derived from human somatic cells through ectopic expression of transcription factors. This landmark discovery has been considered as a major development towards patient-specific iPSC for various biomedical applications. Unlimited self renewal capacity, pluripotency and ease of accessibility to donor tissues contribute to the versatility of iPSC. The therapeutic potential of iPSC in regenerative medicine, cell-based therapy, disease modelling and drug discovery is indeed very promising. Continuous progress in iPSC technology provides clearer understanding of disease pathogenesis and ultimately new optimism in developing treatment or cure for human diseases.


Related Articles

  • In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells. Sakurai, Hidetoshi; Sakaguchi, Yasuko; Shoji, Emi; Nishino, Tokiko; Maki, Izumi; Sakai, Hiroshi; Hanaoka, Kazunori; Kakizuka, Akira; Sehara-Fujisawa, Atsuko // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    Induced pluripotent stem (iPS) cells are generated from adult somatic cells by transduction of defined factors. Given their unlimited proliferation and differentiation potential, iPS cells represent promising sources for cell therapy and tools for research and drug discovery. However, systems...

  • Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells. Tohru Sugawara; Koichiro Nishino; Akihiro Umezawa; Hidenori Akutsu // Stem Cell Research & Therapy;2012, Vol. 3 Issue 2, p1 

    Induced pluripotent stem (iPS) cells, obtained from reprogramming somatic cells by ectopic expression of a defined set of transcription factors or chemicals, are expected to be used as differentiated cells for drug screening or evaluations of drug toxicity and cell replacement therapies. As...

  • Advances and applications of induced pluripotent stem cells. Pietronave, Stefano; Prat, Maria // Canadian Journal of Physiology & Pharmacology;Mar2012, Vol. 90 Issue 3, p317 

    Direct reprogramming of somatic cells into pluripotent cells is an emerging technology for creating patient-specific cells, and potentially opens new scenarios in medical and pharmacological fields. From the discovery of Shinya Yamanaka, who first obtained pluripotent cells from fibroblasts by...

  • Challenges in the clinical application of induced pluripotent stem cells. Sipp, Douglas // Stem Cell Research & Therapy;2010, Vol. 1 Issue 1, p1 

    The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in...

  • Embryo-like features of induced pluripotent stem cells defy legal and ethical boundaries. Meskus, Mianna; de Miguel Beriain, IƱigo // Croatian Medical Journal;dec2013, Vol. 54 Issue 6, p589 

    The article discusses emerging ethical aspects in stem cell science following the successes made in reprogramming adult cells to become induced pluripotent stem (IPS) cells in vitro as well as in vivo conditions. Topics discussed include advantages of reprogramming cells in disease modeling and...

  • Experimental approaches for the generation of induced pluripotent stem cells. Sommer, Cesar A.; Mostoslavsky, Gustavo // Stem Cell Research & Therapy;2010, Vol. 1 Issue 3, p1 

    Derivation of autologous induced pluripotent stem cells (iPSCs) through direct reprogramming of easily accessible somatic cells holds the potential to transform the field of regenerative medicine. Since Takahashi and Yamanaka's groundbreaking study describing the generation of iPSCs by...

  • Research Highlights.  // Molecular Therapy;Dec2012, Vol. 20 Issue 12, p2195 

    The article focuses on several studies related cell therapy. It mentions a report which explains the development of facioscapulohumeral muscular dystrophy (FSHD). It says that a study has identified cellular hindrances to induced pluripotent stem (iPS) cell development which may lead to the...

  • Stem cells: Sweetening pluripotency. Donner, Amy // Nature Chemical Biology;Jul2012, Vol. 8 Issue 7, p602 

    The article offers information on the transformation of somatic cells into induced pluripotent stem cells by the combination of transcription factors which includes octamer binding transcription factor 4 (OCT-4) and SOX2.

  • Notch inhibition allows oncogene-independent generation of iPS cells. Ichida, Justin K; T C W, Julia; Williams, Luis A; Carter, Ava C; Shi, Yingxiao; Moura, Marcelo T; Ziller, Michael; Singh, Sean; Amabile, Giovanni; Bock, Christoph; Umezawa, Akihiro; Rubin, Lee L; Bradner, James E; Akutsu, Hidenori; Meissner, Alexander; Eggan, Kevin // Nature Chemical Biology;Aug2014, Vol. 10 Issue 8, p632 

    The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biomedicine. However, human reprogramming remains inefficient and relies either on the use of the potentially dangerous oncogenes KLF4 and CMYC or the genetic inhibition of the tumor...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics