TITLE

β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting

AUTHOR(S)
Jimenez, Maria; Léger, Bertrand; Canola, Kriss; Lehr, Lorenz; Arboit, Patrizia; Seydoux, Josiane; Russell, Aaron P.; Giacobino, Jean-Paul; Muzzin, Patrick; Preitner, Frédéric
PUB. DATE
October 2002
SOURCE
FEBS Letters;Oct2002, Vol. 530 Issue 1-3, p37
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the β-adrenoceptors (β1/β2/β3). To test this hypothesis, we generated β1/β2/β3-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, β-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.
ACCESSION #
7897839

 

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