Naturally-Acquired Influenza-Specific CD4+ T-Cell Proliferative Responses Are Impaired in HIV-Infected African Adults

Jambo, Kondwani C.; Sepako, Enoch; Glennie, Sarah J.; Mzinza, David; Williams, Neil A.; Gordon, Stephen B.; Heyderman, Robert S.
June 2012
PLoS ONE;Jun2012, Vol. 7 Issue 6, p1
Academic Journal
Background: Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturallyacquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4+ T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART. Methods: Peripheral blood mononuclear cells were isolated from HIV-infected and HIV-uninfected Malawian adults. CFSE proliferation and CD154 expression flow cytometry-based assays were used to measure influenza-specific CD4+ T-cell immunity. Results: We found lower naturally-acquired proliferative influenza-specific CD4+ T-cell responses in AIDS patients that was also present in asymptomatic HIV-infected adults with relatively high CD4 counts (>350 cells/ml). Influenza-specific CD4+ Tcell immune reconstitution in HIV-infected patients on HAART for 12 months was poor despite a marked reduction in viral load and an increase in CD4 count. This poor immune reconstitution was characterised by a low influenza-specific proliferative CD4+ T-cell response and reduced proportions of CD154-expressing influenza-specific CD4+ T-cells in peripheral blood. Conclusion: Our data suggest that asymptomatic HIV-infected adults may also be at risk of influenza-related complications and that HAART alone may not circumvent this risk in AIDS patients. This study highlights the need to identify possible interventions early in HIV infection to reduce the risk of influenza and to intensify influenza surveillance in these susceptible African populations.


Related Articles

  • Bigger T-cell response not necessarily better. Minton, Kirsty // Nature Reviews Immunology;Feb2007, Vol. 7 Issue 2, p88 

    The article discusses a study about T cell response to treat HIV. Many medical researchers focus on using T cell response specifically for HIV in order to prevent progression. The study suggests that it is important to define the specific T cell response for people who have progressed to having...

  • Human Metapneumovirus Infection in HIV Patients. Winslow, Dean L. // Infectious Disease Alert;Apr2010, Vol. 29 Issue 7, p74 

    Fifty consecutive patients from a large HIV clinic in Montreal, who presented with febrile respiratory symptoms (temperature > 38° C and one or more respiratory symptom) from November 2003-April 2006, were recruited for this prospective study. An in-house multiplex realtime PCR assay was...

  • Antibiotic gets star role as HIV wonder drug. Coghlan, Andy // New Scientist;11/27/2004, Vol. 184 Issue 2475, p8 

    The article discusses the use of cotrimoxazole in the treatment of lethal respiratory infections in AIDS patients. Cotrimoxazole last week earned a new and heroic role in the fight against childhood AIDS in Africa, preventing potentially lethal respiratory infections that strike HIV-positive...

  • Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy: A Randomized Controlled Trial. Paton, Nicholas I.; Goodall, Ruth L.; Dunn, David T.; Franzen, Samuel; Collaco-Moraes, Yolanda; Gazzard, Brian G.; Williams, Ian G.; Fisher, Martin J.; Winston, Alan; Fox, Julie; Orkin, Chloe; Herieka, Elbushra A.; Ainsworth, Jonathan G.; Post, Frank A.; Wansbrough-Jones, Mark; Kelleher, Peter // JAMA: Journal of the American Medical Association;7/25/2012, Vol. 308 Issue 4, p353 

    The article presents a study focusing on the effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy. The results of the study show that among HIV-infected patients not taking antiretroviral therapy, the use of...

  • HIV's Evasion of Host's NK Cell Response and Novel Ways of its Countering and Boosting Anti-HIV Immunity. Ahmad, Ali; Ahmad, Rasheed // Current HIV Research;Jul2003, Vol. 1 Issue 3, p295 

    NK cells were characterized by their ability to spontaneously kill certain tumor and virus-infected cells. They constitute first line of defense against invading pathogens and usually become activated in viral infections particularly in early phases. Activated NK cells play a crucial role in the...

  • Herpes simplex virus infection of the central nervous system in human immunodeficiency virus-type 1-infected patients. Grover, D.; Newsholme, W.; Brink, N.; Manji, H.; Miller, R. // International Journal of STD & AIDS;Sep2004, Vol. 15 Issue 9, p597 

    We report clinical, radiological and virological data from nine consecutive HIV-infected patients with herpes simplex virus (HSV) infection of the central nervous system (CNS). Three patients presented with confusion, two with fever and headache, two with anxiety and depression, one with slow...

  • Pandemic and post-pandemic Influenza A (H1N1) infection in critically ill patients.  // Critical Care;2011, Vol. 15 Issue 3, pR286 

    The article focuses on the study conducted to examine pandemic and post-pandemic influenza A (H1N1) infection in patients. It reveals that HIV virus is associated with higher mortality during the post-pandemic Influenza (H1N1)v infection period of patients. Further it concludes that the...

  • Lessons Learned from HIV Treatment Interruption: Safety, Correlates of Immune Control, and Drug Sparing. Azzoni, Livio; Papasavvas, Emmanouil; Montaner, Luis J. // Current HIV Research;Jul2003, Vol. 1 Issue 3, p329 

    Therapeutic approaches seeking to limit the exposure to antiretroviral drugs while retaining the benefits of continuous therapy have become an active area of investigation in HIV therapy research. Although early attempts to use interruptions of therapy as auto-vaccination strategies have shown...

  • Microbial Translocation and HIV Infection. Winslow, Dean L. // Infectious Disease Alert;Jun2010, Vol. 29 Issue 9, p97 

    Twenty-one patients with HIV-1/AIDs, seven patients with HIV-2/AIDS, 43 patients with HIV-1 chronic infection, and 66 patients with HIV-2 chronic infection in Guinea-Bissau were studied along with 66 HIV-negative policemen. LPS was measured by limulus amebocyte lysate assay, and IL-12 and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics