TITLE

Hypocholesterolemic Effects of the LDL Receptor Gene Transcriptional Upregulator CP-230821

AUTHOR(S)
Shimokawa, Teruhiko; Goto, Shoichiro; Ida, Motoko; Goto, Masahide; Nishijima, Satomi; Kodama, Tatsuhiko
PUB. DATE
January 1998
SOURCE
Journal of Biochemistry;1998, Vol. 123 Issue 4, p596
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
CP-230821 is a novel, potent LDL receptor gene transcriptional upregulator which decreases total plasma cholesterol level. Interestingly, this plasma LDL decrease does not alter hepatic lipid contents. A series of experiments was undertaken to study the molecular biology of this phenomenon. Twelve hours after CP-230821 treatment, the transcriptional activity and mRNA level of the LDL receptor gene in HepG2 cells were increased by 264% and 426%, respectively. Although treatment with the HMG-CoA reductase inhibitor compactin also increased LDL receptor gene transcription and mRNA, CP-230821 did not increase the level of HMG-CoA reductase gene transcription or mRNA. These results indicate that LDL receptor gene activity may play an important role in the decrease of plasma LDL level. These results further suggest that the LDL receptor gene and the HMG-CoA reductase gene are not strictly coordinately controlled.
ACCESSION #
80100934

 

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