TITLE

Preparation of Dry Extract of Mikania glomerata Sprengel (Guaco) and Determination of Its Coumarin Levels by Spectrophotometry and HPLC-UV

AUTHOR(S)
e Silva, Luciana Soares; da Silva, Luciane Santos; Brumano, Larissa; Stringheta, Paulo César; de Oliveira Pinto, Miriam Aparecida; Moreira Dias, Leticia Oliveira; Martins Muller, Camila de Sá; Scio, Elita; Fabri, Rodrigo Luiz; Castro, Helena C.; do Amaral, Maria da Penha Henriques
PUB. DATE
September 2012
SOURCE
Molecules;Sep2012, Vol. 17 Issue 9, p10344
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Guaco (Mikania glomerata Sprengel) syrup is one of the most popular herbal medicines used to treat the symptoms of asthmatic bronchitis, cough and hoarseness. The coumarin 2H-1-benzopyran-2-one, is one of the major constituents of Guaco and contributes to its pharmacological effects. The pharmaceutical capsule form of dry extract of Guaco is recommended by the Brazilian Program of Medicinal Plants and Herbal Medicines and used in primary health care. In order to identify a new protocol to obtain the raw material for Guaco capsule production we evaluated two methods, including a freezedrying process (lyophilization) and the spray-dryer technique, as well as the use of two adjuvants, Maltodextrins and Aerosil®, in different concentrations. The coumarin levels of the dried extracts were analyzed by UV-spectrophotometry and HPLC-UV/DAD. The adjuvant Aerosil® 8% showed better dry powder physical appearance. Lyophilization was observed to be the best process to obtain the dry extract of Guaco based on the measured coumarin levels.
ACCESSION #
81281247

 

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