TITLE

Comparative efficacy and safety of intravenous ferric carboxymaltose (Ferinject) and iron(III) hydroxide dextran (Cosmofer) in pregnancy

AUTHOR(S)
Myers, B.; Myers, O.; Moore, J.
PUB. DATE
September 2012
SOURCE
Obstetric Medicine (1753-495X);Sep2012, Vol. 5 Issue 3, p105
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Iron-deficiency anaemia is common in pregnancy, with well-described maternal morbidities. When oral iron therapy has failed, intravenous (IV) preparations are considered. Ferric carboxymaltose (ferinject) is a new IV preparation which can be given quickly. There are no published data on Ferinject use in pregnancy. This study analyses historical data from women given Cosmofer, compared with those given Ferinject in pregnancy, to assess comparative efficacy and safety. Methods: Pregnant women treated with Cosmofer and Ferinject, were identified from pharmacy records. Records for all cases were reviewed and those which fulfilled inclusion criteria selected. The inclusion criteria included: symptomatic iron-deficient anaemia unresponsive to oral iron; age ≥18; second to third trimester; full blood count taken at least once at two, four and/or six weeks postinfusion. Data were collected on the pre-treatment Hb, ferritin, and same data collected at two, four and six weeks after the infusion. Side-effects or adverse reactions were noted for both the Cosmofer and Ferinject patients. Results: Results were obtained for 92 women (44 received Ferinject and 48 Cosmofer). Pre-infusion Hb and ferritin levels were comparable in the two groups. At two weeks, the mean Hb rise in the Ferinject group was 1.73 g/dL and 1.34 g/dL in the Cosmofer group. At four weeks, the total rise in Hb was 2.57 g/dL Ferinject, 2.34 g/dL Cosmofer. At six weeks the rise was 3.01 g/dL and 3.2 g/dL respectively. No serious adverse events were reported in either group. Conclusion: Both preparations appear effective and safe, with low risk of serious adverse effects and side-effects.
ACCESSION #
82357209

 

Related Articles

  • Plant Ferritin—A Source of Iron to Prevent Its Deficiency. Zielińska-Dawidziak, Magdalena // Nutrients;2015, Vol. 7 Issue 2, p1184 

    Iron deficiency anemia affects a significant part of the human population. Due to the unique properties of plant ferritin, food enrichment with ferritin iron seems to be a promising strategy to prevent this malnutrition problem. This protein captures huge amounts of iron ions inside the...

  • Strategies for the Prevention and Treatment of Iron Deficiency during Pregnancy. Remacha, A.F. // Clinical Drug Investigation;2000 Supplement 1, Vol. 19 Issue 6, p29 

    Iron deficiency is the most frequent micronutrient deficiency in humans. It is especially prevalent in certain risk groups, which, because of their elevated requirements, include pregnant women and women of childbearing age. During pregnancy the parameters of iron metabolism are altered, and...

  • Iron supplementation. Smith, H. // Professional Nursing Today;2012, Vol. 16 Issue 6, p9 

    The article discusses the supplementation of iron in human physiology. It mentions its inherent part in proteins and enzymes that maintain better health. It also notes its vital role in the delivery and storage of oxygen in the body which is a constituent of haemoglobin, myoglobin and other...

  • Clinical digest. PREGNANT WOMEN BENEFIT FROM TAKING IRON INTERMITTENTLY.  // Nursing Standard;8/15/2012, Vol. 26 Issue 50, p14 

    The article discusses research which was reported in the article "Intermittent Oral Iron Supplementation During Pregnancy" by J. Pena-Rosas et al. and found that pregnant women benefit from taking iron once or twice a week.

  • An iron fish that is fighting anaemia in Cambodia. Bradley, Peter // British Journal of Healthcare Assistants;Aug2015, Vol. 9 Issue 8, p412 

    The article features the Lucky Iron Fish, a cast iron ingot that provides bioavailable iron, developed by a Canadian research group in Kandal, Cambodia headed by student Christopher Charles. Topics covered include the prevalence of dietary anemia in 44% of the population in Cambodia, the...

  • Iron Deficiency Often Overlooked in Irritable Bowel Patients. Credi, Elizabeth // Holistic Primary Care;Fall2014, Vol. 15 Issue 3, p6 

    The article discusses iron deficiency anemia (IDA) as a complication of inflammatory bowel disease (IBD). Topics mentioned include the study "Inflammatory Bowel Diseases" by Dr. Jeffery Hertzberg on anemia as the most common cause of hospitalization among patients with IBD, difficulties...

  • Iron deficiency: The developing child at risk. O'Sullivan, Siobhan // World of Irish Nursing & Midwifery;Mar2013, Vol. 21 Issue 2, p41 

    No abstract available.

  • all about iron. Murray, Michael T. // Better Nutrition;Mar2014, Vol. 76 Issue 3, p32 

    The article discusses the health benefits, deficiency and dietary food sources of iron in human health. It mentions the role of iron in the hemoglobin molecule of human red blood cells (RBC) and its function of transporting oxygen from lungs to body's tissues. It explores the factors which can...

  • LIFE-CHANGING FISH. Klein, Andrew // Science World;9/21/2015, Vol. 72 Issue 2, p12 

    The article offers information on the Lucky Iron Fish that Canadian graduate student Christopher Charles has created to help combat iron deficiency which causes anemia in Cambodia.

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics