TITLE

Why, when and how insulin therapy is being started for patients with type 2 diabetes treated with oral medications: an observation study

AUTHOR(S)
Dudzińska, Marta; Tarach, Jerzy S.; Malicka, Joanna; Kurowska, Maria; Kowalczyk, Mariusz; Nowakowski, Andrzej
PUB. DATE
July 2011
SOURCE
Experimental & Clinical Diabetology / Diabetologia Doswiadczalna;2011, Vol. 11 Issue 2, p45
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Secondary failure of oral medications is observed annually in 10% of diabetic patients. Introducing insulin therapy is the next stage in the model of progressive treatment of type 2 diabetes. The aim of the study was to evaluate the indications for insulin therapy and to determine which insulin preparations and models of their administration were the most frequently used in a group of patients with type 2 diabetes who started insulin treatment. Material and methods. The study involved 68 patients with type 2 diabetes (38 F, 30 M), mean age was 63.1 ± ± 10.1 years. Results. At the start of insulin therapy the mean HbA1c level in the entire group of patients was 8.2%, including 8.7% in persons with secondary failure of oral medications, 7.9% in the subgroup showing symptoms of intolerance to oral medications taken so far, and 6.3% in patients with contraindications for continuing treatment with oral medication due to accompanying diseases. Combining therapy insulin was administered in 64.7% of patients (n = 44), while insulin monotherapy -- in 35.3% of patients (n = 24). Insulin treatment was usually based on human classic insulins (66.2%), and less frequently on analogues (33.85%). A model of insulin therapy based on one injection per day was used in 39.7% of patients (n = 27), two injections per day -- 41.2% of patients (n = 28). The remaining patients were administered insulin three times per day (8.8%, n = 6) or underwent intensive insulin therapy (10.3%, n = 7). Conclusion. The main indication for introducing insulin therapy was secondary failure of oral medications. Insulin therapy was usually started with the use of human classic insulins administered in the form of two or one injection per day. These were combined with the oral medications the patients had been taking, which facilitated the transition to insulin injection.
ACCESSION #
84510976

 

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