Dynamics of Pneumocystis carinii Air Shedding During Experimental Pneumocystosis

Choukri, Firas; Aliouat, El Moukhtar; Menotti, Jean; Totet, Anne; Gantois, Nausicaa; Garin, Yves J. F.; Bergeron, Vance; Dei-cas, Eduardo; Derouin, Francis
May 2011
Journal of Infectious Diseases;May2011, Vol. 203 Issue 9, p1333
Academic Journal
To better understand the diffusion of Pneumocystis in the environment, airborne shedding of Pneumocystis carinii in the surrounding air of experimentally infected rats was quantified by means of a real-time polymerase chain reaction assay, in parallel with the kinetics of P. carinii loads in their lungs. P. carinii DNA was detected in the air 1 week after infection and increased until 4–5 weeks after infection before stabilizing. A significant correlation was shown between lung burdens and the corresponding airborne levels, suggesting the possibility of estimating the fungal lung involvement through quantification of Pneumocystis in the exhaled air.


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