TITLE

Research Highlights

PUB. DATE
January 2013
SOURCE
Molecular Therapy;Jan2013, Vol. 21 Issue 1, p4
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article offers information on several studies related to gene and cell therapy. It mentions a study which showed the use of induced pluripotent stem (iPS) cells in examining the response of diseased cells to drugs. It says that a drug which can increase antisense oligonucleotide therapy's effectiveness for treating Duchenne muscular dystrophy (DMD) was revealed in another study. It adds that a study found the existence of somatic copy-number variations (CNVs) in skin fibroblasts' genomes.
ACCESSION #
84622353

 

Related Articles

  • Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells. Massouridès, Emmanuelle; Polentes, Jérôme; Mangeot, Philippe-Emmanuel; Mournetas, Virginie; Nectoux, Juliette; Deburgrave, Nathalie; Nusbaum, Patrick; Leturcq, France; Popplewell, Linda; Dickson, George; Wein, Nicolas; Flanigan, Kevin M.; Peschanski, Marc; Chelly, Jamel; Pinset, Christian // Skeletal Muscle;11/14/2015, Vol. 5, p1 

    Background: Duchenne muscular dystrophy (DMD) is a devastating X-linked recessive genetic myopathy. DMD physiopathology is still not fully understood and a prenatal onset is suspected but difficult to address. Methods: The bone morphogenetic protein 4 (BMP4) is a critical signaling molecule...

  • Negligible Immunogenicity of Induced Pluripotent Stem Cells Derived from Human Skin Fibroblasts. Lu, Qiao; Yu, Meixing; Shen, Chongyang; Chen, Xiaoping; Feng, Ting; Yao, Yongchao; Li, Jinrong; Li, Hong; Tu, Wenwei // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Human induced pluripotent stem cells (hiPSCs) have potential applications in cell replacement therapy and regenerative medicine. However, limited information is available regarding the immunologic features of iPSCs. In this study, expression of MHC and T cell co-stimulatory molecules in hiPSCs,...

  • IPSCs Won't Grow Up. Breindl, Anette // BioWorld Today;7/1/2013, Vol. 24 Issue 125, p1 

    The article reports on the findings by researchers from Kyoto University in Japan that most fibroblasts which are treated with a cocktail of four factors to reprogram them into induced pluripotent stem cells (iPSCs) acquire pluripotency markers, but only few were able establish colonies of iPSCs...

  • Psychiatric disorders: Modelling lithium responsiveness in a dish. Whalley, Katherine // Nature Reviews Neuroscience;Dec2015, Vol. 16 Issue 12, p702 

    The article discusses the study regarding the development of an induced pluripotent stem cell- (iPSC) based model of bipolar disorder (BD) through reprogramming fibroblasts. It references the study "Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder,"...

  • Wild-Type Mouse Models to Screen Antisense Oligonucleotides for Exon-Skipping Efficacy in Duchenne Muscular Dystrophy. Cao, Limin; Han, Gang; Gu, Ben; Yin, HaiFang // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    A readily available animal model is essential for rapidly identifying effective treatments for Duchenne muscular dystrophy (DMD), a devastating neuromuscular disorder caused by the lack of dystrophin protein, which results from frame-disrupting mutations in the DMD gene. Currently, the mdx mouse...

  • Tbx3: another important piece fitted into the pluripotent stem cell puzzle. Pirity, Melinda K.; Dinnyes, Andras // Stem Cell Research & Therapy;2010, Vol. 1 Issue 2, p1 

    Induced pluripotent stem cells (iPSCs) are novel tools for biomedical research, with a promise for future regenerative medicine applications. Recently, Han and colleagues reported in Nature that T box gene 3 (Tbx3) can improve the quality of mouse iPSCs and increase their germline transmission...

  • The Potential of iPS Cells in Synucleinopathy Research. Linta, Leonhard; Stockmann, Marianne; Boeckers, Tobias M.; Kleger, Alexander; Liebau, Stefan // Stem Cells International;2012, p1 

    α-synuclein is a protein involved in the pathogenesis of several so-called synucleinopathies including Parkinson's disease. A variety of models have been so far assessed. Human induced pluripotent stem cells provide a patient- and disease-specific model for in vitro studies,...

  • The fate of cell reprogramming. Karagiannis, Peter; Yamanaka, Shinya // Nature Methods;Oct2014, Vol. 11 Issue 10, p1006 

    The article presents the authors' opinion on cell reprogramming and the ability to convert somatic cells to induced pluripotent stem cells which has potential to further understanding of development and disease mechanisms, as well as for cellular therapy. The authors say researchers must expand...

  • INDUCED PLURIPOTENT STEM CELLS: HOW THEY WILL CHANGE THE PRACTICE OF CARDIOVASCULAR MEDICINE. Wing Tak Wong; Sayed, Nazish; Cooke, John P. // Methodist DeBakey Cardiovascular Journal;Oct-Dec2013, Vol. 9 Issue 4, p206 

    Induced pluripotent stem cells (iPSCs) can be generated from adult somatic tissues by the forced expression of a few defined transcription factors, including Oct4, Sox2, Klf4, and c-Myc. iPSC technology holds tremendous promises for therapeutic cardiovascular regeneration because of the cells'...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics