MR-Based PET Motion Correction Procedure for Simultaneous MR-PET Neuroimaging of Human Brain

Ullisch, Marcus Görge; Scheins, Jürgen Johann; Weirich, Christoph; Rota Kops, Elena; Celik, Abdullah; Tellmann, Lutz; Stöcker, Tony; Herzog, Hans; Shah, Nadim Jon
November 2012
PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1
Academic Journal
Positron Emission Tomography (PET) images are prone to motion artefacts due to the long acquisition time of PET measurements. Recently, simultaneous magnetic resonance imaging (MRI) and PET have become available in the first generation of Hybrid MR-PET scanners. In this work, the elimination of artefacts due to head motion in PET neuroimages is achieved by a new approach utilising MR-based motion tracking in combination with PET list mode data motion correction for simultaneous MR-PET acquisitions. The method comprises accurate MR-based motion measurements, an intra-frame motion minimising and reconstruction time reducing temporal framing algorithm, and a list mode based PET reconstruction which utilises the Ordinary Poisson Algorithm and avoids axial and transaxial compression. Compared to images uncorrected for motion, an increased image quality is shown in phantom as well as in vivo images. In vivo motion corrected images show an evident increase of contrast at the basal ganglia and a good visibility of uptake in tiny structures such as superior colliculi.


Related Articles

  • Modelling Treatment Response Could Reduce Virological Failure in Different Patient Populations. Revell, Andrew D.; Wang, Dechao; d'Ettorre, Gabriella; DE Wolf, Frank; Gazzard, Brian; Ceccarelli, Giancarlo; Gatell, Jose; Pérez-elías, María Jésus; Vullo, Vincenzo; Montaner, Julio S.; Lane, H. Clifford; Larder, Brendan A. // Journal of AIDS & Clinical Research;Special2012, Vol. 3 Issue S, Special section p1 

    Background: HIV drug resistance can cause viral re-bound in patients on combination antiretroviral therapy, requiring a change in therapy to re-establish virological control. The RDI has developed computational models that predict response to combination therapy based on the viral genotype,...

  • Characterization of HIV-1 Genotypes and Antiretroviral Drug-resistance Mutations among Patients in Burkina Faso. Kagone, T. S.; Hien, H.; Meda, N.; Diagbouga, P. S.; Sawadogo, A.; Drabo, J.; Peeters, M.; Vergne, L.; Delaporte, E.; De Souza, C.; Gbeassor, M.; Simpore, J. // Pakistan Journal of Biological Sciences;2011, Vol. 14 Issue 6, p392 

    No abstract available.

  • Incidence of Resistance in a Double-Blind Study Comparing Lopinavir/Ritonavir Plus Stavudine and Lamivudine to Nelfinavir plus Stavudine and Lamivudine. Kempf, Dale J.; King, Martin S.; Bernstein, Barry; Cernohous, Paul; Bauer, Eric; Moseley, Jennifer; Kai Gu, Jennifer; Hsu, Ann; Brun, Scott; Sun, Eugene // Journal of Infectious Diseases;1/1/2004, Vol. 189 Issue 1, p51 

    Reports on the incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine in anteroretroviral therapy-naive human immunodeficiency virus (HIV) type 1-infected subjects. Study methods; Primary mutations...

  • Resistance analyses in HIV infected patients with a history of multiple antiretroviral treatment regimens. Plettenberg, Andreas; Albrecht, Dirk; Lorenzen, Thore; Paech, Volker; Petersen, Heiko; Fenner, Thomas; Meyer, Thomas; Arndt, Rudiger; Hertogs, Kurt; Pauwels, Rudi; Weitzel, Thomas; Stoehr, Albrecht; Plettenberg, A; Albrecht, D; Lorenzen, T; Paech, V; Petersen, H; Fenner, T; Meyer, T; Arndt, R // Sexually Transmitted Infections;Dec2001, Vol. 77 Issue 6, p449 

    Objective: To assess HIV-1 isolate based resistance profiles from extensively pretreated patients and effects of a resistance guided switch of antiretroviral therapy.Methods: In a prospective study phenotypic and genotypic resistance analyses were performed on HIV...

  • The effect of valacyclovir on HIV and HSV-2 in HIV-infected persons on antiretroviral therapy with previously unrecognised HSV-2. Van Wagoner, Nicholas; Geisler, William M; Bachmann, Laura H; Hook, Edward W // International Journal of STD & AIDS;Jul2015, Vol. 26 Issue 8, p574 

    In the absence of antiretroviral therapy, valacyclovir may reduce HIV viral load and increase CD4+ T-lymphocyte count. We sought to evaluate the impact of valacyclovir on HIV and HSV-2 in co-infected patients receiving antiretroviral therapy with previously unrecognised HSV-2 infection. A...

  • Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism. Kane, Michael J.; Angoa-Peréz, Mariana; Briggs, Denise I.; Sykes, Catherine E.; Francescutti, Dina M.; Rosenberg, David R.; Kuhn, Donald M. // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    Autism is a complex neurodevelopmental disorder characterized by impaired reciprocal social interaction, communication deficits and repetitive behaviors. A very large number of genes have been linked to autism, many of which encode proteins involved in the development and function of synaptic...

  • Ultradeep sequencing in the therapeutic management of HIV-1 infection at treatment initiation. Todesco, Eve; Mercier-Darty, Mélanie; Jung, Matthieu; Bottero, Julie; Boyd, Anders; Marcelin, Anne-Geneviève; Calvez, Vincent; Morand-Joubert, Laurence // Journal of Antimicrobial Chemotherapy (JAC);Jun2015, Vol. 70 Issue 6, p1919 

    The article describes the case of an HIV-positive patient who showed decreases in treatment resistance mutations. Particular focus is given to the patient's plasma viral load, as well as the ultradeep sequencing (UDS) method. Also mentioned are the initiation of antiretroviral therapy (ART),...

  • Virological Control during the First 6--18 Months after Initiating Highly Active Antiretroviral Therapy as a Predictor for Outcome in HIV-Infected Patients: A Danish, Population-Based, 6-Year Follow-Up Study. Lohse, Nicolai; Kronborg, Gitte; Gerstoft, Jan; Larsen, Carsten Schade; Pedersen, Gitte; Pedersen, Court; Toft Sørensen, Henrik; Obel, Niels // Clinical Infectious Diseases;1/1/2006, Vol. 42 Issue 1, p136 

    Background. Our objective was to examine whether virological control during the first 6-18 months after HAART initiation is a predictor for viral suppression, CD4+ cell count increase, and mortality in human im- munodeficiency virus (HIV)-infected patients 18-90 months after initiation of highly...

  • Delaying HIV treatment increases risk of mortality. Roehr, Bob // BMJ: British Medical Journal (International Edition);11/8/2008, Vol. 337 Issue 7678, p1073 

    The article reports on the results of a detailed analysis which was conducted on data which was taken from 22 HIV cohort studies that were conducted in the United States and Canada. The results suggested that delaying the start of an antiretroviral treatment in people with with a CD4 T cell...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics