TITLE

Study of various vitamin D3 supplementation protocols in healthy adult volunteers with hypovitaminosis D

AUTHOR(S)
Pawal, P. S.; Sharma, B.; Mittal, S.; Joshi, A.; Lathia, T.; Bhagwat, N.; Chadha, M.; Varthakavi, P.
PUB. DATE
December 2012
SOURCE
Indian Journal of Endocrinology & Metabolism;Dec2012 Supplement, Vol. 16, pS521
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Hypovitaminosis D, which has various skeletal and extraskeletal manifestations, is widely prevalent in India (70-95%). Different dosing protocols have been used for Vitamin D (VITD) supplementation. This study is designed to compare various supplemental regimens. Aim and Objectives: Comparison of serial VITD concentrations attained with various VITD supplementation protocols in VITD deficient subjects. Materials and Methods: A total of 242 healthy volunteers (20-60 years: BMI 21-26 kg/m2), were screened for vitamin D deficiency. Out of this, 139 subjects were deficient, and 105 consenting subjects with VITD <16 ng/ml were randomized to receive four different supplemental regimens, i.e., single dose 6 lac IU orally, 6 lac IU intramuscular, 60,000 IU once weekly for 8 weeks, and 2000 IU daily for 8 weeks. VITD, parathyroid hormone, calcium, phosphorus, alkaline phosphatase were monitored at 0, 1, 3, 6, 8, 12, and 16 weeks of therapy. Results: Conclusions: 1 All groups showed rise in VITD at 1 week. 2 At 3 weeks, there was a fall in VITD in 6 lac IU oral group, while a steady rising trend was observed in the other three groups. 3 Six subjects in Oral 6 lac group attained toxic levels of VITD while none from other groups developed toxic levels. Final results will be presented at ESICON2012.
ACCESSION #
85601671

 

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