TITLE

ANTI-FUNGAL ACTIVITY OF MICROEMULSION BASED FLUCONAZOLE GEL FOR ONYCHOMYCOSIS AGAINST ASPERGILLUS NIGER

AUTHOR(S)
RAJA KUMAR, K. JAYA; MURALIDHARAN, SELVADURAI; ARUMUGAM DHANARAJ, SOKKALINGAM
PUB. DATE
January 2013
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Jan-Mar2013, Vol. 5 Issue 1, p96
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Oral dosing of an antifungal agent could prove to be a cost-effective way to provide long-term treatment for fungal nail infections and less permeability of drug topical delivery. The endeavor of the present study was to evaluate microemulsion as a vehicle for topical drug delivery and to expand microemulsion-based gel of fluconazole for the treatment of onychomycosis. Experimental design was adopted to optimize the amount of oil (oleic acid), mixture of surfactant (tween 80), cosurfactant (propylene glycol) and water in the microemulsion. The optimized formulations of fluconazole microemulsion based gel were assessed for viscosity, zeta potential, spreadability, gel strength, mucoadhesive force, globule size, FTIR, and SEM. The viscosity of plain gel was found to be in the range 24995 to 61000 cps, whereas for the microemulsion loaded gel was up to 30000 cps. The maximum gel strength and mucoadhesion was found to be up to 145 seconds and 13141.51dynes/cm2 respectively. Scanning electron microscopy showed that globules were spherical in shape. Drug containing microemulsion was converted into gel employing 1%, 1.5, 1.75% w/v of xanthan gum. The optimized gel showed better penetration and mucoadhesive properties as compared to the commercial gel. The cumulative percentage of drug release after 7 h for optimized MBGs was 72.23%. Fluconazole microemulsion based gel form showed better activity against Aspergillus niger than the commercial gel. It was concluded that drug-loaded gel could be a promising formulation for effective treatment of onychomycosis.
ACCESSION #
85723658

 

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