Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells

Jirmanova, Ludmila; Afanassieff, Marielle; Gobert-Gosse, Stephanie; Markossian, Suzy; Savatier, Pierre
August 2002
Oncogene;8/15/2002, Vol. 21 Issue 36, p5515
Academic Journal
Presents a study that investigated the role of MEK-extracellular signal-regulated kinase (ERK) and P13-kinase signalling pathways ion in the control of the steady-state level of cyclin D1 and of G1/S transition in mouse embryonic stem (ES) cells. Background on ES cells; Differential contributions of ERK and phosphatidylinositol 3 (PI3)-kinase signallings to the regulation of cyclin D1 level in ES cells; Regulation of cyclin D1 expression and of PI3-kinase activity by nitrogen stimulation.


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