TITLE

EFFICACY OF GYMNEMA SYLVESTRE IN ALLEVIATION OF STREPTOZOTOCIN INDUCED DIABETES IN RATS

AUTHOR(S)
Mallikarjuna, G.; Rao, Suguna; Shridhar, N. B.; Sathyanarayana, M. L.; Byregowda, S. M.; Ravikumar, P.
PUB. DATE
March 2013
SOURCE
International Journal of Advanced Biological Research;2013, Vol. 3 Issue 1, p51
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A hydroalcoholic extract of Gymnema sylvestre leaves (100 mg/kg b w / day) was tested for its biochemical and pathomorphological effects in streptozotocin induced diabetes in rats. Streptozotocin produced diabetes effectively in all the animals at 45 mg/kg in citrate buffer intraperitonially with a significant (P≤0.001) increase in the mean (± SE) serum levels of glucose, cholesterol, triglycerides, ALT and AST and a significant reduction in serum insulin in diabetic rats. Gymnema sylvestre extract supplement significantly (P≤0.001) reduced the serum levels glucose, cholesterol, triglycerides, ALT and AST from Day 3 post treatment till the end of the study with significant improvement in serum insulin levels (P≤0.001) in diabetic animals. Gymnema sylvestre also alleviated the damage caused by STZ morphologically in beta cells of islets of Langerhans and hepatocytes. However the effect was not totally comparable to that produced by glibenclamide in diabetic rats.
ACCESSION #
86893774

 

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