In vivo modulation of Hmgic reduces obesity

Anand, Ashim; Chada, Kiran
April 2000
Nature Genetics;Apr2000, Vol. 24 Issue 4, p377
Academic Journal
The HMGI family of proteins consists of three members, HMGIC, HMGI and HMGI(Y), that function as architectural factors and are essential components of the enhancesome. HMGIC is predominantly expressed in proliferating, undifferentiated mesenchymal cells and is not detected in adult tissues. It is disrupted and misexpressed in a number of mesenchymal tumour cell types, including fat-cell tumours (lipomas). In addition Hmgic?/? mice have a deficiency in fat tissue. To study its role in adipogenesis and obesity, we examined Hmgic expression in the adipose tissue of adult, obese mice. Mice with a partial or complete deficiency of Hmgic resisted diet-induced obesity. Disruption of Hmgic caused a reduction in the obesity induced by leptin deficiency (Lepob/Lepob) in a gene-dose?dependent manner. Our studies implicate a role for HMGIC in fat-cell proliferation, indicating that it may be an adipose-specific target for the treatment of obesity.


Related Articles

  • Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond. Jin-Ying Lu; Kuo-Chin Huang; Lin-Chau Chang; Ying-Shing Huang; Yu-Chiao Chi; Ta-Chan Su; Chi-Ling Chen; Wei-Shiung Yang // Journal of Biomedical Science;Sep2008, Vol. 15 Issue 5, p565 

    Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many other human diseases. From animal experiments and human studies, adiponectin has been shown to be a key regulator of...

  • Sexual Dimorphism in Clock Genes Expression in Human Adipose Tissue. Gómez-Abellán, P.; Madrid, J.; Luján, J.; Frutos, M.; González, R.; Martínez-Augustín, O.; Medina, F.; Ordovás, J.; Garaulet, M. // Obesity Surgery;Jan2012, Vol. 22 Issue 1, p105 

    Background: This study was carried out to investigate whether sex-related differences exist in the adipocyte expression of clock genes from subcutaneous abdominal and visceral fat depots in severely obese patients. Methods: We investigated 16 morbidly obese patients, eight men and eight women...

  • Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state. Nannipieri, M.; Bonotti, A.; Anselmino, M.; Cecchetti, F.; Madec, S.; Mancini, E.; Baldi, S.; Santini, F.; Pinchera, A.; Rossi, M.; Ferrannini, E. // International Journal of Obesity;Dec2007, Vol. 31 Issue 12, p1843 

    Objective:To investigate whether adiponectin receptor genes (AdipoR1 and AdipoR2) expression in human subcutaneous (SAT) and visceral (VAT) adipose tissue in severely obese patients with or without diabetes is related to adiponectin gene (APM1) expression and in vivo metabolic...

  • Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice. Koza, Robert A.; Nikonova, Larissa; Hogan, Jessica; Jong-Seop Rim; Mendoza, Tamra; Faulk, Christopher; Skaf, Jihad; Kozak, Leslie P. // PLoS Genetics;May2006, Vol. 2 Issue 5, pe81 

    High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat diet beginning at 8 wk of age resulted in a 4-fold difference in adiposity. The phenotypes of mice characteristic...

  • Adipose Tissue: Something More than Just Adipocytes. Alemany, Marià; Fernández-López, José Antonio // Current Nutrition & Food Science;2006, Vol. 2 Issue 2, p141 

    Obesity is correlated with low-grade inflammation, which provides a potential link between insulin resistance and the endothelial dysfunction present in the early stages of the atherosclerotic process. Adipose tissue has been considered until recently, just a depot for energy storage, which has...

  • Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Poitou, C.; Viguerie, N.; de Cancello, R.; de Matteis, R.; Cinti, S.; Stich, V.; Coussieu, C.; Gauthier, E.; Courtine, M.; Zucker, J. D.; Barsh, G. S.; Saris, W.; Bruneval, P.; Basdevant, A.; Langin, D.; Clément, K. // Diabetologia;Mar2005, Vol. 48 Issue 3, p519 

    Aims/hypothesis: The acute-phase proteins, serum amyloid As (SAA), are precursors of amyloid A, involved in the pathogenesis of AA amyloidosis. This work started with the characterisation of systemic AA amyloidosis concurrent with SAA overexpression in the subcutaneous white adipose tissue...

  • Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Boucher, J.; Quilliot, D.; Pradères, J. P.; Simon, M. F.; Grès, S.; Guigné, C.; Prévot, D.; Ferry, G.; Boutin, J. A.; Carpéné, C.; Valet, P.; Saulnier-Blache, J. S. // Diabetologia;Mar2005, Vol. 48 Issue 3, p569 

    Aims/hypothesis: Autotaxin is a lysophospholipase D that is secreted by adipocytes and whose expression is substantially up-regulated in obese, diabetic db/db mice. The aim of the present study was to depict the physiopathological and cellular mechanisms involved in regulation of adipocyte...

  • Attenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice. McCurdy, Carrie E.; Schenk, Simon; Holliday, Michael J.; Philp, Andrew; Houck, Julie A.; Patsouris, David; MacLean, Paul S.; Majka, Susan M.; Klemm, Dwight J.; Friedman, Jacob E. // Diabetes;Oct2012, Vol. 61 Issue 10, p2495 

    Obese white adipose tissue (AT) is characterized by large-scale infiltration of proinflammatory macrophages, in parallel with systemic insulin resistance; however, the cellular stimulus that initiates this signaling cascade and chemokine release is still unknown. The objective of this study was...

  • Expression of Lipolytic Genes in Adipose Tissue Is Differentially Regulated During Multiple Phases of Dietary Intervention in Obese Women. KOPPO, K.; VALLE, C.; ŠIKLOVÁ-VÍTKOVÁ, M.; CZUDKOVÁ, E.; DE GLISEZINSKI, I.; VAN DE VOORDE, J.; LANGIN, D.; ŠTICH, V. // Physiological Research;2013, Vol. 62 Issue 5, p527 

    The aim of this study was to investigate the time-course of the expression of key lipolysis-regulating genes in the subcutaneous adipose tissue (SCAT) during different phases of a 6-month dietary intervention. Fifteen obese women (BMI 34.7±1.0 kg.m-2) underwent a 6-month dietary intervention...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics