TITLE

The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

AUTHOR(S)
Wang, Jiali; Liu, Rong; Liu, LiSen; Chowdhury, Rahena; Barzilai, Nir; Tan, Jianzhen; Rossetti, Luciano
PUB. DATE
August 1999
SOURCE
Nature Medicine;Aug1999, Vol. 5 Issue 8, p895
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression in skeletal muscle, a tissue that normally does not express this gene. Changes in nutrient availability resulted in rapid alterations in Lep autoregulation. These findings demonstrate negative feedback regulation of Lep in fat, and indicate that leptin secretion can function as a vehicle of 'cross-talk' between adipose tissue and skeletal muscle, leading to tissue-specific modulation of the 'leptin signal'.
ACCESSION #
8817495

 

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