In vitro models of mucosal HIV transmission

Shattock, Robin J; Griffin, George E; Gorodeski, George I
June 2000
Nature Medicine;Jun2000, Vol. 6 Issue 6, p607
Academic Journal
Comments on an article by Kelly Collins et al on vitro models of mucosal HIV transmission published in the April 2000 issue of 'Nature Medicine' periodical. Absence of data which showed that controls were used to eliminate the possibility that inoculating virus has access to the tissue; Interpretation of the claim of Collins et al that transmission of the virus occurred in majority of examined tissue.


Related Articles

  • Transmission of Human Immunodeficiency Virus (HIV) by Transplantation: Clinical Aspects and Time Course Analysis of Viral Antigenemia and Antibody Production. Bowen, P. Allen; Lobel, Steven A.; Caruana, Ralph J.; Leffell, Mary S.; House, Mary A.; Rissing, J. Peter; Humphries, Arthur L. // Annals of Internal Medicine;Jan88, Vol. 108 Issue 1, p46 

    Presents a study which investigated a case of transmission of an HIV infection by a renal allograft and present data on the time course of viral antigenemia and antibody production in the allograft recipient. Result of a blockage in the entry of circulating virus into the CD4-positive cells by...

  • CAPRISA 004 Tenofovir Microbicide Trial: No Impact of Tenofovir Gel on the HIV Transmission Bottleneck. Valley-Omar, Ziyaad; Sibeko, Sengeziwe; Anderson, Jeffrey; Goodier, Sarah; Werner, Lise; Arney, Leslie; Naranbhai, Vivek; Treurnicht, Florette; Abrahams, Melissa-Rose; Bandawe, Gama; Swanstrom, Ronald; Karim, Quarraisha Abdool; Karim, Salim S. Abdool; Williamson, Carolyn // Journal of Infectious Diseases;Jul2012, Vol. 206 Issue 1, p35 

    Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a...

  • Antivirals: Helping hand for HIV. Hughes, Bethan // Nature Reviews Drug Discovery;Feb2008, Vol. 7 Issue 2, p120 

    The article features a study concerning the role of semen-derived amyloid fibrils in enhancing human immunodeficiency infections (HIVs). They identified the prostatic acidic phosphatase fragments by examining a complex/protein library of human semen for factors involved in the HIV transmission...

  • Inter-linkages Between Culture and Gender in HIV transmission in Zambia. Menon, J. A. // Medical Journal of Zambia;2014, Vol. 41 Issue 2, p100 

    Introduction: The current Zambian adult HIV prevalence stand at 14% with a gender bias of more women (16.1%) living with HIV and AIDS compared to men (12.3%).Hence the aim of this review was to gain an in-depth understanding of the linkages between culture, gender and HIV transmission in Zambia...

  • Perinatal Transmission of Human Immunodeficiency Virus Type 1 by Pregnant Women with RNA Virus Loads <1000 Copies/mL. Ioannidis, John P. A.; Abrams, Elaine J.; Ammann, Arthur; Bulterys, Marc; Goedert, James J.; Gray, Linsay; Korber, Bette T.; Mayaux, Marie Jeanne; Mofenson, Lynne M.; Newell, Marie-Louise; Shapiro, David E.; Teglas, Jean Paul; Wilfert, Catherine M. // Journal of Infectious Diseases;2/15/2001, Vol. 183 Issue 4, p538 

    Features a study which identified cases of vertical human immunodeficiency virus type I transmission among women with RNA virus loads at delivery or at the measurement closest to delivery in Europe and United States. Eligibility criteria for the transmission registry; International registry...

  • FROM THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES.  // Ethnicity & Disease;Spring2009, Vol. 19 Issue 2, p225 

    The article discusses the results of the HPTN 035 study which examined the ability of PRO 2000 and BufferGel vaginal gels to prevent HIV infection transmission. It says that PRO 2000 hinders HIV cell entry while BufferGel increases vagina's natural acidity which can help deactivate HIV. It...

  • Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals. Greenier, Jennifer L.; Van Rompay, Koen K. A.; Montefiori, David; Earl, Patricia; Moss, Bernard; Marthas, Marta L. // Virology Journal;2005, Vol. 2, p11 

    Background: Oral infection of infant macaques with simian immunodeficiency virus (SIV) is a useful animal model to test interventions to reduce postnatal HIV transmission via breast-feeding. We previously demonstrated that immunization of infant rhesus macaques with either modified vaccinia...

  • Mechanisms by which co-infections modify HIV-1 transmission. John-Stewart, Grace C. // Retrovirology;2008 Supplement 1, Vol. 5, Special section p1 

    Women with HIV-1 are frequently co-infected with other pathogens that may influence transmission of HIV-1. Bacterial, helminth, and viral infections are prevalent in settings with high HIV-1 prevalence and may be associated with immune activation, increased HIV-1 replication and genital...

  • Dendritic Cells and HIV-1 Trans-Infection. McDonald, David // Viruses (1999-4915);Aug2010, Vol. 2 Issue 8, p1704 

    Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics