TITLE

The Gln27Glu polymorphism in the β2-adrenergic receptor gene is not associated with morbid obesity in Austrian women

AUTHOR(S)
Oberkofler, H; Esterbauer, H; Hell, E; Krempler, F; Patsch, W
PUB. DATE
March 2000
SOURCE
International Journal of Obesity & Related Metabolic Disorders;Mar2000, Vol. 24 Issue 3, p388
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE:β-adrenergic receptors (βARs) play an important role in the regulation of energy expenditure and lipid mobilization. A GI-27Glu polymorphism in the β[sub 2]-adrenergic receptor (β[sub 2]AR) gene has recently been associated with several indices of obesity in a female Caucasian population, while the same polymorphism exhibited no association with obesity in another, albeit male, population. METHODS: We have therefore studied possible associations of the GIn27Glu and the Gly16Arg polymorphisms in the β[sub 2]AR with BMI, plasma leptin and UCP-1 mRNA expression in the intraperitoneal adipose tissue in a population of Caucasian women. RESULTS: The frequencies of the Gin27 and the Gly16 alleles as well as the β[sub 2]AR haplotypes were similar in our morbidly obese and lean subjects. Furthermore, no association was found between the GIn27Glu or the Gly16Arg polymorphisms and plasma leptin or adipose tissue UCP-1 gene expression in either group. CONCLUSIONS: We conclude that the two polymorphisms in the β[sub 2]AR gene studied are not a major factor contributing to obesity in our population.
ACCESSION #
8853582

 

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