Impact of polymorphisms of the human β2-adrenoceptor gene on obesity in a French population

Meirhaeghe, A; Helbecque, N; Cottel, D; Amouyel, P
March 2000
International Journal of Obesity & Related Metabolic Disorders;Mar2000, Vol. 24 Issue 3, p382
Academic Journal
OBJECTIVE: To investigate the impact of two common polymorphisms in the human β[sub 2]-adrenoceptor gene (Gly16Arg and GIn27Glu substitutions) on obesity and anthropometric measurements as well as blood variables in a large sample of a French population. DESIGN AND SUBJECTS: Within the framework of the WHO-MONICA project, a population study composed of 1195 subjects aged 35-64y was randomly sampled from the electoral rolls of the Urban Community of Lille, in northern France. Subjects without any medical treatment (for hypercholesterolaemia, hypertension or diabetes mellitus) susceptible to interfere with body weight and biological variables were selected (n=836, 419men/417 women, age = 49.5 ± 8.1y, body mass index (BMI)=25.7±4.4kg/m²). Subjects with a body mass index ≥30kg/m² were considered as obese (n = 119, age = 49.5 ± 8.2 y, BMI = 33.9 ± 3.3 kg/m² range 30- 44). MEASUREMENTS: Genotyping was carried out with allele-specific oligonucleotides hybridization. Association between genotypes and various obesity markers (body weight, body mass index, waist and waist-to-hip ratio), lipid, glucose and insulin variables were studied. RESULTS: The Gly16Arg and GIn27Glu polymorphisms were in complete linkage disequilibrium. GIn27GIn subjects had an increased risk of obesity (odds ratio (OR) = 1.77, 95% CI 1.19-2.62, P= 0.005). This effect was mainly detected in men (OR = 2.40, 95% CI 1.34-4.27, P= 0.003). Men bearing the GIn27GIn genotype had higher body weight, BMI, waist and hip circumferences and waist-to-hip ratio than others. Moreover, if GIn27GIn men carried in addition the Arg16 allele, the increase in body weight, BMI and waist-to-hip ratio was more important. CONCLUSION: Our results suggest that genetic variability of the β2-adrenoceptor gene is implicated in body weight regulation and in the onset of obesity in French men.


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