Frequency of and interaction between polymorphisms in the β3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans

Evans, D; Minouchehr, S; Hagemann, G; Mann, W A; Wendt, D; Wolf, A; Beisiegel, U
October 2000
International Journal of Obesity & Related Metabolic Disorders;Oct2000, Vol. 24 Issue 10, p1239
Academic Journal
OBJECTIVE: To determine the role of polymorphisms in the genes for β3-adrenergic receptor (β3-AR) and in uncoupling proteins 1 and 2 (UCP-1, UCP-2) in obesity. DESIGN: Association study with three polymorphisms and obesity. SUBJECTS: Two hundred and thirty-six morbidly obese patients who underwent gastric banding surgery, 381 patients from the medical clinic and 198 healthy blood donors. MEASUREMENTS: The frequencies of the W64R in β3-AR, the -3826A→G in UCP-1 and the 45 bp insertion in the 3′ untranslated region of exon 8 in UCP-2 polymorphisms were determined. RESULTS: There were no significant differences in the frequencies of the β3-AR and UCP-1 polymorphisms between obese (body mass index, BMI>30 kg/m2) and lean subjects. Lean, but not obese, carriers of the R allele of β3-AR had a significantly higher BMI. The mean age of obese subjects (excluding diabetics) who were carriers of the G allele of the UCP-1 polymorphism, 36 y, was significantly younger than wild-type, 40 y (P=0.007). This effect was not seen in lean subjects. The effect of the G allele on the mean age of obese subjects was more apparent in subjects who were also carriers of the R allele of the β3-AR polymorphism. The frequency of the ins allele of UCP-2 was significantly higher in obese subjects, 0.31, than in lean, 0.24 (P=0.002) and carriers of the ins allele had a significantly higher BMI, 38 vs 35 (P=0.005). There was no association between any of the polymorphisms and type II diabetes. CONCLUSION: In a German population, there was no association between the W64R in β3-AR or the -3826A→G in UCP-1 polymorphisms and obesity. However, they act synergistically to accelerate the development of obesity. The 45 bp insertion in the 3′ untranslated region of exon 8 in UCP-2 polymorphism is associated with obesity. International Journal of Obesity (2000) 24, 1239–1245


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