Estrategias farmacológicas para facilitar la adherencia a la terapia antirretroviral altamente activa

Clapé-Laffita, Oneyda
March 2013
Revista Medica del IMSS;2013, Vol. 51 Issue 2, p200
Academic Journal
Background: adherence to antiretroviral therapy is an important factor in achieving human immunodeficiency virus suppression. The aim was to apply a pharmacological strategy, based in pharmacokinetics measures for improving the adherence to antiretroviral therapy. Methods: We did a descriptive study for eight months in 75 human immunodeficiency virus positive patients with clinical and social criteria for highly active antiretroviral therapy in Opuwo, Namibia. Pharmacological aspects, such as major side effects and dangerous drug-drug interactions, were evaluated. Descriptive statistics analysis were applied. Results: three minor side effects were detected (two for efavirenz and one for nevirapine), and one major side effect for stavudine/lamivudine. Dangerous drug interactions were avoided doing pharmacokinetics measures with efavirenz, stavudine/lamivudine and zidovudine; and between nevirapine and fluconazol or ketoconazol. Conclusions: the adherence to highly active antiretroviral therapy was improved with the application of the proposed pharmacological strategy to avoid side effects and dangerous drug interactions.


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