Hu, G. M.; Shen, G. M.; Xu, H.
October 2012
Acta Endocrinologica (1841-0987);Oct-Dec2012, Vol. 8 Issue 4, p529
Academic Journal
Background: Cimicifuga racemosa (CR) is widely used in the treatment of menopausal symptoms, including hormonerelated affective disorders in women. Mechanistic studies suggest that unlike hormone-replacement therapy, CR does not stimulate cancerous growth. Objective: to evaluate CR safety and the antidepressant-like effects compared to estrogen treatment. Materials and Methods: we used the forced swimming test (FST) to address the hypotheses that CR alters behavior of ovariectomized (OVX) rats in the FST and the FST-induced expression of c-fos in the rat paraventricular nucleus (PVN). After the FST, all animals were perfused, and the brains were processed for c-fos immunocytochemistry; the plasma was processed for radioimmunoassay of plasma estrogen levels. Results: OVX group animals spent significantly (P<0.05) more time struggling than CR and E2 groups. The CR and E2 groups animals spent little time in immobility, whereas OVX group animals increased their time in immobility as their struggle time decreased. CR and E2 groups animals spent significantly (P< 0.05) more time swimming than OVX group animals Conclusion: CR was demonstrated to have antidepressant effect, and establishing the safety of CR for treatment of menopausal symptoms in women in whom hormone-replacement therapy is contraindicated.


Related Articles

  • Estrogen plus progestin reduced the incidence of diabetes in postmenopausal women with coronary heart disease. Smith, Donald A. // ACP Journal Club;Sep/Oct2003, Vol. 139 Issue 2, p39 

    Presents a study that analyzed the effectiveness of estrogen plus progestin hormone replacement therapy in preventing an increase in fasting glucose level and reducing the incidence of diabetes in postmenopausal women with coronary heart disease. Design; Intervention; Outcome measures; Results;...

  • Estrogen, Estrogen Receptors and Rupture of Brain Aneurysms: Brief Review of the Literature. Navas-Marrugo, Sandy Zuleica; Alvis-Miranda, Hernando Raphael; Gutierrez-Paternina, Juan Jose; Alcala-Cerra, Gabriel; Moscote-Salazar, Luis Rafael // Romanian Neurosurgery;2014, Vol. 21 Issue 3, p293 

    Estrogen, is involved in much of the life women lives, having great importance in many functions of the female body including the definition of secondary sexual characters, but also has been linked as protective factor regard to catastrophic events such as cerebral aneurysms, probably related to...

  • Effect of Pulsed Estrogen Therapy on Hemostatic Markers in Comparison with Oral Estrogen Regimen in Postmenopausal Women. Basurto, Lourdes; Saucedo, Renata; Zárate, Arturo; Martínez, Carlos; Gaminio, Elizabeth; Reyes, Elba; Hernandez, Marcelino // Gynecologic & Obstetric Investigation;Feb2006, Vol. 61 Issue 2, p61 

    Background/Aims: Hormone replacement therapy (HRT) is associated with an increased risk of thromboembolism dependent on the type of HRT; therefore, we compared therapy effects of intranasal with oral estrogens on coagulation and fibrinolysis markers in postmenopausal women. Methods: A randomized...

  • Hormone therapy: Benefits of a combined regimen.  // American Family Physician;2/15/1996, Vol. 53 Issue 3, p962 

    Presents the study `Combined Continuous Hormone Replacement Therapy: A Critical Review,' by L. Udoff, et al., published in the 1995 issue of `Obstetrics and Gynecology.' Result of the clinical trial on the effectiveness of combined estrogen and progestin therapy; Complications prevented by...

  • Is Estrogen for You? Manson, Joann E.; Bassuk, Shari S. // Newsweek (Pacific Edition);5/8/2006 (Pacific Edition), Vol. 147 Issue 19, p46 

    The article discusses the risks of hormone therapy for menopausal women. The authors note that estrogen may be linked with an increased risk of heart disease. The authors also mention that hormone therapy is likely to be more beneficial for women who start therapy early in menopause. For...

  • Estrogen did not prevent death or nonfatal stroke in postmenopausal women with ischemic stroke or TIA. McNagny, Sally E. // ACP Journal Club;May/Jun2002, Vol. 136 Issue 3, p96 

    Comments on a study which investigated a clinical trial of estrogen-replacement therapy after ischemic stroke. Outcome measures; Effectiveness of estrogen and placebo in preventing death or nonfatal stroke on postmenopausal women with ischemic stroke or transient ischemic attack; Information on...

  • How to help women come off HRT. Mansour, Diana // Pulse;3/22/2004, Vol. 64 Issue 12, p60 

    Offers advice on how to help women withdraw from hormone replacement therapy (HRT). Prescription of HRT for menopausal women; Assessment of when women should stop taking HRT; Techniques in HRT withdrawal including the use of oral estrogen-only preparations, cyclical combined therapy and...

  • Hormone Replacement Therapy and High S Phase in Breast Cancer. Cobleigh, Melody A.; Norlock, Frances E.; Oleske, Denise M.; Starr, Alexander // JAMA: Journal of the American Medical Association;4/28/99, Vol. 281 Issue 16, p1528 

    Presents research which compared the prognostic characteristics of cancers arising in women who used hormone replacement therapy (HRT) with those who did not. Increased incidence of breast cancer and reduced breast cancer mortality in women using HRT; Design; Setting; Patients; Main outcome...

  • Menopausal Symptoms after the Discontinuation of Long-Term Hormone Replacement Therapy in Women under 60: A 3-Year Follow-Up. Perrone, Giuseppina; Capri, Oriana; Galoppi, Paola; Patacchioli, Francesca R.; Bevilacqua, Elisa; de Stefano, Maria G.; Brunelli, Roberto // Gynecologic & Obstetric Investigation;Aug2013, Vol. 76 Issue 1, p38 

    Background: Prescriptions for hormone replacement therapy (HRT) declined following the publication of the Women's Health Initiative study. The number of women who experience recurrence of menopausal symptoms after discontinuation of long-term HRT (LT-HRT), the length of time these symptoms last...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics