Hu, G. M.; Shen, G. M.; Xu, H.
October 2012
Acta Endocrinologica (1841-0987);Oct-Dec2012, Vol. 8 Issue 4, p529
Academic Journal
Background: Cimicifuga racemosa (CR) is widely used in the treatment of menopausal symptoms, including hormonerelated affective disorders in women. Mechanistic studies suggest that unlike hormone-replacement therapy, CR does not stimulate cancerous growth. Objective: to evaluate CR safety and the antidepressant-like effects compared to estrogen treatment. Materials and Methods: we used the forced swimming test (FST) to address the hypotheses that CR alters behavior of ovariectomized (OVX) rats in the FST and the FST-induced expression of c-fos in the rat paraventricular nucleus (PVN). After the FST, all animals were perfused, and the brains were processed for c-fos immunocytochemistry; the plasma was processed for radioimmunoassay of plasma estrogen levels. Results: OVX group animals spent significantly (P<0.05) more time struggling than CR and E2 groups. The CR and E2 groups animals spent little time in immobility, whereas OVX group animals increased their time in immobility as their struggle time decreased. CR and E2 groups animals spent significantly (P< 0.05) more time swimming than OVX group animals Conclusion: CR was demonstrated to have antidepressant effect, and establishing the safety of CR for treatment of menopausal symptoms in women in whom hormone-replacement therapy is contraindicated.


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