Cell therapy in the heart

Abdelli, Latifa S.; Merino, Hilda; Rocher, Crystal M.; Singla, Dinender K.
March 2012
Canadian Journal of Physiology & Pharmacology;Mar2012, Vol. 90 Issue 3, p307
Academic Journal
Cell therapy is emerging as a new strategy to circumvent the adverse effects of heart disease. Many experimental and clinical studies investigating the transplantation of cells into the injured myocardium have yielded promising results. Moreover, data from these reports show that transplanted stem cells can engraft within the myocardium, differentiate into major cardiac cell types, and improve cardiac function. However, results from clinical trials show conflicting results. These trials demonstrate significant improvements in cardiac function for up to 6 months. However, these improved functions were diminished when examined at 18 months. In this review, we will discuss the current literature available on cell transplantation, covering studies ranging from animal models to clinical trials.


Related Articles

  • Safer Way to Produce Stem Cell Alternative Demonstrated. ANDRUSKO, DAVE // National Right to Life News;Mar2009, Vol. 36 Issue 3, p12 

    The article discusses research being done on a new way to more safely reprogram adult stem cells which can provide a virtually limitless supply of embryonic-like stem cells called induced pluripotent stem (iPS) cells. It references studies by Andras Nagy and Keisuke Kaji, published in "Nature."...

  • Nuclear Magnetic Resonance Detects Phosphoinositide 3-Kinase/Akt-Independent Traits Common to Pluripotent Murine Embryonic Stem Cells and Their Malignant Counterparts. Romanska, Hanna M.; Tiziani, Stefano; Howe, Rachael C.; G√ľnther, Ulrich L.; Gulzar, Zulfiqar; Lalani, El-Nasir // Neoplasia;Dec2009, Vol. 11 Issue 12, p1301 

    Pluripotent embryonic stem (ES) cells, a potential source of somatic precursors for cell therapies, cause tumors after transplantation. Studies of mammalian carcinogenesis using nuclear magnetic resonance (NMR) spectroscopy have revealed changes in the choline region, particularly increased...

  • Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection. Noguchi, H; Saitoh, I; Tsugata, T; Kataoka, H; Watanabe, M; Noguchi, Y // Cell Death & Differentiation;Jan2015, Vol. 22 Issue 1, p145 

    Although induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem (ES) cells, there are still several unresolved issues related to the use of iPS cells for clinical applications, such as teratoma formation. In...

  • Engineered embryonic stem cells for regnerative nedicine. Hescheler, J. // Cell Research;Aug2008 Supplement, Vol. 18, pS111 

    Due to their ability to reproduce the embryological differentiation of nearly all different cellular phenotypes, embryonic stem (ES) cells represent an ideal tool to study processes of embryogenesis under in vitro conditions, in particular the signalling cascades and genes involved in the...

  • ES cells overexpressing microRNA-1 attenuate apoptosis in the injured myocardium. Glass, Carley; Singla, Dinender // Molecular & Cellular Biochemistry;Nov2011, Vol. 357 Issue 1/2, p135 

    MicroRNAs (miRs) are small, single-stranded, noncoding RNA's involved in post-transcriptional negative gene regulation. Recent investigations have underscored the integral role of miRs in various biological processes including innate immunity, cell-cycle regulation, metabolism, differentiation,...

  • Japan okays stem cells. Saegusa, Asako // Nature Biotechnology;Mar2000, Vol. 18 Issue 3, p246 

    Reports on the approval given by the bioethics committee of Japan's Science and Technology Council for research involving the use of embryonic stem cells. Reason cited by the committee for granting approval to the research; Plans of the committee to draw up guidelines for embryonic stem cell...

  • Scientists react to government indecision. Brown, Phyllida // Nature Medicine;Aug1999, Vol. 5 Issue 8, p855 

    Discusses the government's delay in deciding whether to permit research into the therapeutic use of human embryonic stem cells in Great Britain. Creation of anti-science climate; Reaction of the researchers towards the delay.

  • Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Osakada, Fumitaka; Ikeda, Hanako; Mandai, Michiko; Wataya, Takafumi; Watanabe, Kiichi; Yoshimura, Nagahisa; Akaike, Akiori; Sasai, Yoshiki; Takahashi, Masayo // Nature Biotechnology;Mar2008, Vol. 26 Issue 3, p352 

    A correction to the article "Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells" that was published in the February 3, 2008 issue is presented.

  • Long-Awaited, Global Trial of Fetal Cells for Parkinson's. Fox, Cynthia // Bioscience Technology;7/21/2014, p1 

    The article discusses the global trial of the fetal cell transplant for Parkinson's diseases (PD) patients and embryonic stem (ES) cell PD therapies highlighted at the 2014 International Society for Stem Cell Research (ISSCR) meeting. Topics discussed include an outline of the fetal cell...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics