TITLE

The FTO Gene rs9939609 Polymorphism Predicts Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis

AUTHOR(S)
Liu, Chibo; Mou, Sihua; Pan, Chunqin
PUB. DATE
August 2013
SOURCE
PLoS ONE;Aug2013, Vol. 8 Issue 8, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Genome-wide association studies have shown that variance in the fat mass- and obesity- associated gene (FTO) is associated with risk of obesity in Europeans and Asians. Since obesity is associated with an increased risk of cardiovascular disease (CVD), several studies have investigated the association between variant in the FTO gene and CVD risk, with inconsistent results. In this study, we performed a meta-analysis to clarify the association of rs9939609 variant (or its proxies [r2>0.90]) in the FTO gene with CVD risk. Methods: Published literature from PubMed and Embase was retrieved. Pooled odds ratios with 95% confidence intervals were calculated using the fixed- or random- effects model. Results: A total of 10 studies (comprising 19,153 CVD cases and 103,720 controls) were included in the meta-analysis. The results indicated that the rs9939609 variant was significantly associated with CVD risk (odds ratio = 1.18, 95% confidence interval = 1.07–1.30, p = 0.001 [Z test], I2 = 80.6%, p<0.001 [heterogeneity]), and there was an insignificant change after adjustment for body mass index (BMI) and other conventional CVD risk factors (odds ratio = 1.16, 95% confidence interval = 1.05–1.27, p = 0.003 [Z test], I2 = 75.4%, p<0.001 [heterogeneity]). Conclusions: The present meta-analysis confirmed the significant association of the rs9939609 variant in the FTO gene with CVD risk, which was independent of BMI and other conventional CVD risk factors.
ACCESSION #
90071888

 

Related Articles

  • UGT1A1*6 polymorphisms are correlated with irinotecan-induced toxicity: a system review and meta-analysis in Asians. Cheng, Lei; Li, Ming; Hu, Jing; Ren, Wei; Xie, Li; Sun, Zhan-Peng; Liu, Bao-Rui; Xu, Gen-Xing; Dong, Xiao-Liang; Qian, Xiao-Ping // Cancer Chemotherapy & Pharmacology;Mar2014, Vol. 73 Issue 3, p551 

    Purpose: Previous studies confirmed that genotyping uridine diphosphate glucuronosyltransferase (UGT) 1A1*28 polymorphisms could predict the side effects in cancer patients using irinotecan (IRI) and then reduce IRI-induced toxicity by preventative treatment or decrease in dose. However, the...

  • Mediterranean Diet and Cardiodiabesity: A Review. García-Fernández, Elena; Rico-Cabanas, Laura; Rosgaard, Nanna; Estruch, Ramón; Bach-Faig, Anna // Nutrients;Sep2014, Vol. 6 Issue 9, p3474 

    Cardiodiabesity has been used to define and describe the well-known relationship between type 2 Diabetes Mellitus (T2DM), obesity, the metabolic syndrome (MetS) and cardiovascular disease (CVD). The objective of this study was to perform a scientific literature review with a systematic search to...

  • Bariatrische Chirurgie effektiver als konservative Behandlungen -- nicht nur bei Adipositas. Markun, Stefan // Praxis (16618157);3/12/2014, Vol. 103 Issue 6, p347 

    No abstract available.

  • Association between alcohol and cardiovascular disease: mendelian randomisation analysis based on individual participant data. Casas, J. P. // BMJ: British Medical Journal;7/12/2014, Vol. 349 Issue 7966, pg4164 

    The article discusses research which investigated clinical association between alcohol consumption and cardiovascular disease risks. Topics explored include the evaluation of the cardiovascular health impact of alcohol intake, the identification of the genetic variant linked to low alcohol...

  • Challenges and Limitations in the Interpretation of Systematic Reviews: Making Sense of Clopidogrel and CYP2C19 Pharmacogenetics. Sorich, M J; Polasek, T M; Wiese, M D // Clinical Pharmacology & Therapeutics;Sep2013, Vol. 94 Issue 3, p376 

    From 2010 to 2012, nine systematic reviews reported highly variable conclusions regarding the association between carriage of a cytochrome P450 2C19 loss-of-function allele and the risk of adverse cardiovascular (CV) events in individuals using clopidogrel. Possible contributors to the variable...

  • Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies. Abril-Ulloa, Victoria; Flores-Mateo, Gemma; Solà-Alberich, Rosa; Manuel-y-Keenoy, Begoña; Arija, Victoria // BMC Public Health;2014, Vol. 14 Issue 1, p517 

    Background Elevated ferritin levels have been associated with single cardiovascular risk factors but the relationship to the presence of metabolic syndrome is inconclusive. The aim of this systematic review and meta-analysis of published observational studies was to estimate the association...

  • Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events. Lewis, Evan J. H.; Sethi, Ankur; Singh, Mukesh; Arora, Rohit; Vlachopoulos, Charalambos; Richter, Dimitrios; Stefanadis, Christodoulos; Galli, Claudio; Brenna, J. Thomas; Rizos, Evangelos C.; Ntzani, Evangelia E. // JAMA: Journal of the American Medical Association;1/2/2013, Vol. 309 Issue 1, p27 

    Several letters to the editor is presented in response to the article "Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis" by E.C. Rizos and colleagues in a 2012 issue of the periodical along with response...

  • Ambulatory Blood Pressure Monitoring in Individuals with HIV: A Systematic Review and Meta-Analysis. Kent, Shia T.; Bromfield, Samantha G.; Burkholder, Greer A.; Falzon, Louise; Oparil, Suzanne; Overton, Edgar T.; Mugavero, Michael J.; Schwartz, Joseph E.; Shimbo, Daichi; Muntner, Paul // PLoS ONE;2/16/2016, Vol. 11 Issue 2, p1 

    Introduction: Abnormal diurnal blood pressure (BP) rhythms may contribute to the high cardiovascular disease risk in HIV-positive (HIV+) individuals. To synthesize the current literature on ambulatory BP monitoring (ABPM) in HIV+ individuals, a systematic literature review and meta-analysis...

  • The Impact of Traditional Cardiovascular Risk Factors on Cardiovascular Outcomes in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Baghdadi, Leena R.; Woodman, Richard J.; Shanahan, E. Michael; Mangoni, Arduino A. // PLoS ONE;Feb2015, Vol. 10 Issue 2, p1 

    Background: Rheumatoid arthritis (RA) is known to increase the risk of cardiovascular (CV) disease. However, the individual impact of traditional CV risk factors in RA is unknown. Objective: To assess the strength of the association between individual CV risk factors and rate of either...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics